AIM2 Inhibitors
The chemical class of AIM2 inhibitors encompasses a diverse array of compounds that directly or indirectly modulate the activity of the AIM2 protein, a key player in the inflammasome-mediated innate immune response. These inhibitors can be broadly categorized into two groups based on their mechanisms of action. Direct inhibitors such as VX-765, Belnacasan, CY-09, and Z-VAD-FMK specifically target AIM2 or the downstream signaling components involved in AIM2 inflammasome assembly. VX-765 and Belnacasan directly inhibit caspase-1, a crucial enzyme in the AIM2 inflammasome activation pathway, disrupting the downstream signaling events. CY-09 uniquely binds to AIM2's PYD domain, preventing inflammasome assembly. Z-VAD-FMK, a pan-caspase inhibitor, provides a broad-spectrum inhibition of caspases, including caspase-1, affecting AIM2-related cellular responses.
Indirect modulators such as MCC950, Oridonin, Thalidomide, Rosmarinic Acid, A438079, Bay 11-7082, CAPE, and Parthenolide influence AIM2 activity through pathways outside the direct AIM2 inflammasome assembly. MCC950, an NLRP3 inflammasome inhibitor, indirectly impacts AIM2 by targeting a shared downstream signaling pathway. Oridonin and Thalidomide affect NF-κB signaling, influencing AIM2-related responses. Rosmarinic Acid and CAPE modulate oxidative stress, providing insights into the redox-dependent regulation of AIM2. A438079 and Bay 11-7082 impact purinergic signaling and NF-κB activation, respectively, contributing to the regulation of AIM2-mediated inflammation. This chemical class of AIM2 inhibitors offers a comprehensive toolkit for researchers investigating the intricacies of AIM2 inflammasome activation and its broader implications in innate immunity. The diversity in mechanisms, ranging from direct caspase inhibition to indirect modulation of inflammasome-related pathways, provides nuanced insights into the regulatory networks governing AIM2 function in various cellular contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VX-765 | 273404-37-8 | sc-475845 sc-475845A sc-475845B | 5 mg 10 mg 50 mg | $228.00 $302.00 $968.00 | 1 | |
VX-765, a caspase-1 inhibitor, directly targets the enzymatic activity of caspase-1. By inhibiting caspase-1, VX-765 disrupts the downstream signaling involved in AIM2 inflammasome activation. This direct inhibition provides a specific tool for studying the molecular mechanisms underlying AIM2 inflammasome activation and its role in innate immune responses. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
Z-VAD-FMK, a pan-caspase inhibitor, directly targets caspases, including caspase-1. By inhibiting caspases, Z-VAD-FMK disrupts the downstream signaling cascades associated with AIM2 inflammasome activation. This direct inhibition offers a versatile tool for studying the broader implications of caspase-mediated processes and their connections to AIM2-related cellular responses. | ||||||
Oridonin, R. rubescens | 28957-04-2 | sc-202751 | 5 mg | $77.00 | ||
Oridonin, a diterpenoid compound, indirectly modulates AIM2 by affecting NF-κB signaling. By inhibiting NF-κB, Oridonin disrupts the transcriptional regulation of inflammatory genes, indirectly influencing AIM2-related responses. This indirect modulation provides a tool for investigating the interconnected signaling pathways governing AIM2 activation and the broader regulatory networks orchestrating inflammatory processes. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide, an immunomodulatory drug, indirectly influences AIM2 by modulating cytokine production. By affecting the expression of pro-inflammatory cytokines, Thalidomide indirectly impacts AIM2-related responses. This indirect modulation offers insights into the immunomodulatory properties of Thalidomide and its potential implications in regulating AIM2-mediated inflammation. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $58.00 $109.00 | 4 | |
Rosmarinic Acid, a natural polyphenolic compound, indirectly modulates AIM2 by affecting ROS production. By inhibiting ROS generation, Rosmarinic Acid influences AIM2-related oxidative stress responses. This indirect modulation provides a tool for studying the redox-dependent regulation of AIM2 and its potential connections to cellular stress pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082, an NF-κB inhibitor, indirectly influences AIM2 by modulating the NF-κB signaling pathway. By inhibiting NF-κB activation, Bay 11-7082 disrupts the transcriptional regulation of inflammatory genes, indirectly impacting AIM2-related responses. This indirect modulation provides a tool for investigating the interplay between NF-κB signaling and AIM2 activation, shedding light on the regulatory mechanisms governing AIM2-mediated inflammatory processes. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
Caffeic Acid Phenethyl Ester (CAPE), a natural polyphenolic compound, indirectly modulates AIM2 by affecting ROS production. By inhibiting ROS generation, CAPE influences AIM2-related oxidative stress responses. This indirect modulation provides a tool for studying the redox-dependent regulation of AIM2 and its potential connections to cellular stress pathways. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, an NF-κB inhibitor, indirectly influences AIM2 by modulating the NF-κB signaling pathway. By inhibiting NF-κB activation, Parthenolide disrupts the transcriptional regulation of inflammatory genes, indirectly impacting AIM2-related responses. This indirect modulation provides a tool for investigating the interplay between NF-κB signaling and AIM2 activation, shedding light on the regulatory mechanisms governing AIM2-mediated inflammatory processes. | ||||||