AHRR Antibody (5G11): sc-293297

AHRR Antibody (5G11) is a mouse monoclonal IgG2a kappa light chain antibody that detects AHRR protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AHRR antibody (5G11) is available as a non-conjugated format. AHRR, also known as aryl-hydrocarbon receptor repressor or bHLHe77, is a 701 amino acid protein encoded by a gene located on human chromosome 5p15.33, which exists in three alternatively spliced isoforms. AHRR plays a crucial role in regulating dioxin toxicity and is involved in cell growth regulation and differentiation. Initially localized in the cytoplasm, AHRR interacts with Arnt 1 protein and translocates to the nucleus, where AHRR exerts regulatory functions. AHRR contains a basic helix-loop-helix (bHLH) domain and a PAS (PER-ARNT-SIM) domain, which are essential for interaction with other proteins and DNA. AHRR is highly expressed in various tissues, including testis, lung, ovary, spleen, pancreas, kidney, and thymus, as well as in mononuclear cells from umbilical cord blood. Notably, AHRR autoregulates expression by binding to its own xenobiotic response element (XRE) site, thereby competing with Ah receptor for heterodimer formation with Arnt 1 and subsequently binding to XRE sequence in the promoter. This mechanism allows AHRR to suppress transcriptional activity of CYP1A1 and may link AHRR to conditions such as male infertility and endometriosis susceptibility.

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AHRR Antibody (5G11) References:

1. Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis.  |  Fujita, H., et al. 2002. Teratology. 65: 10-8. PMID: 11835227
2. Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells.  |  Yamamoto, J., et al. 2004. Life Sci. 74: 1039-49. PMID: 14672759
3. Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins.  |  Watanabe, M., et al. 2004. Fertil Steril. 82 Suppl 3: 1067-71. PMID: 15474075
4. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity.  |  Tsuchiya, M., et al. 2005. Fertil Steril. 84: 454-8. PMID: 16084889
5. The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility.  |  Merisalu, A., et al. 2007. Fertil Steril. 88: 854-9. PMID: 17559847
6. Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines.  |  Haarmann-Stemmann, T., et al. 2007. Drug Metab Dispos. 35: 2262-9. PMID: 17890447
7. Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor.  |  Kanno, Y., et al. 2007. Biochem Biophys Res Commun. 364: 1026-31. PMID: 17980155
8. The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.  |  Zudaire, E., et al. 2008. J Clin Invest. 118: 640-50. PMID: 18172554
9. SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor.  |  Oshima, M., et al. 2009. J Biol Chem. 284: 11017-26. PMID: 19251700
10. The complex biology of aryl hydrocarbon receptor activation in cancer and beyond.  |  Opitz, CA., et al. 2023. Biochem Pharmacol. 216: 115798. PMID: 37696456
11. Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease.  |  Zhang, H., et al. 2024. Nat Commun. 15: 595. PMID: 38238335
12. AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.  |  Monjé, N., et al. 2024. Br J Cancer. 130: 1249-1260. PMID: 38361045

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AHRR Antibody (5G11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-AHRR Antibody (5G11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AHRR Antibody (5G11) Specifications

Alternate Product Name: AHRR

Product Clone Name: 5G11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 617-715

Epitope Target: AHRR

Epitope Species: human

Product Reactivity/Detection: AHRR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for AHRR Antibody (5G11): N/A