AGXT2L2 Antibody (C-11): sc-365670

AGXT2L2 Antibody (C-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects AGXT2L2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AGXT2L2 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AGXT2L2, also known as alanine-glyoxylate aminotransferase 2-like 2, plays a crucial role in amino acid metabolism, specifically in the conversion of glyoxylate to glycine, utilizing L-alanine as the amino donor. This enzymatic activity is vital for maintaining metabolic balance and preventing the accumulation of toxic metabolites, which can lead to various health issues. AGXT2L2 is a 450 amino acid protein that forms a homotetramer and is localized in the mitochondria, where AGXT2L2 participates in critical metabolic pathways. AGXT2L2 is encoded by a gene located on human chromosome 5q35.3 and exists in three alternatively spliced isoforms, suggesting a complex regulatory mechanism that may allow for tissue-specific functions or responses to metabolic demands. Elevated levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been associated with conditions such as diabetes and hypertension, highlighting the importance of AGXT2L2 in cardiovascular health and metabolic regulation.

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AGXT2L2 Antibody (C-11) References:

1. Peroxisomal alanine: glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana.  |  Liepman, AH. and Olsen, LJ. 2001. Plant J. 25: 487-98. PMID: 11309139
2. Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis.  |  Liepman, AH. and Olsen, LJ. 2003. Plant Physiol. 131: 215-27. PMID: 12529529
3. Alanine glyoxylate aminotransferase deficiency: biochemical and molecular genetic lessons from the study of a human disease.  |  Watts, RW. 1992. Adv Enzyme Regul. 32: 309-27. PMID: 1496924
4. Glycolate and glyoxylate metabolism in HepG2 cells.  |  Baker, PR., et al. 2004. Am J Physiol Cell Physiol. 287: C1359-65. PMID: 15240345
5. The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.  |  Dixon, MJ., et al. 1991. Am J Hum Genet. 49: 17-22. PMID: 1676560
6. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.  |  Du, HY., et al. 2007. Aging Cell. 6: 689-97. PMID: 17875000
7. Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.  |  De Gennaro Colonna, V., et al. 2009. Med Sci Monit. 15: RA91-101. PMID: 19333216
8. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.  |  Rodionov, RN., et al. 2010. J Biol Chem. 285: 5385-91. PMID: 20018850
9. Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney.  |  Lee, IS., et al. 1995. J Biochem. 117: 856-62. PMID: 7592550

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AGXT2L2 Antibody (C-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-AGXT2L2 Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AGXT2L2 Antibody (C-11) Specifications

Alternate Product Name: AGXT2L2

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 381-450

Epitope Target: AGXT2L2

Epitope Species: human

Product Reactivity/Detection: AGXT2L2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for AGXT2L2 Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin