AGR2 Antibody (6C5): sc-101211

AGR2 Antibody (6C5) is a mouse monoclonal IgG2b kappa light chain antibody that detects AGR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AGR2 antibody (6C5) is available as the non-conjugated format. AGR2, or Anterior Gradient Protein 2, is a crucial secretory protein that plays a significant role in various cellular processes, particularly in the context of cancer. AGR2 is encoded by two different transcripts and interacts with specific proteins such as LYPD3 and α-dystroglycan (DAG-1), which are important for cell signaling and adhesion. AGR2 expression is notably up-regulated in several types of cancers, including prostate, breast, lung, renal, and endometrial carcinomas, making AGR2 a potential therapeutic marker for these diseases. Furthermore, AGR2 expression shows a positive correlation with estrogen receptor levels while being negatively correlated with epidermal growth factor receptor levels, highlighting AGR2′s importance in cancer biology and potential as a target for therapeutic intervention.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

AGR2 Antibody (6C5) References:

1. Comparison of proteomic and genomic analyses of the human breast cancer cell line T47D and the antiestrogen-resistant derivative T47D-r.  |  Huber, M., et al. 2004. Mol Cell Proteomics. 3: 43-55. PMID: 14557597
2. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer.  |  Zhang, JS., et al. 2005. Genes Chromosomes Cancer. 43: 249-59. PMID: 15834940
3. Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas.  |  Liu, D., et al. 2005. Cancer Res. 65: 3796-805. PMID: 15867376
4. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.  |  Zheng, W., et al. 2006. Genes Immun. 7: 11-8. PMID: 16222343
5. Detection of new methicillin-resistant Staphylococcus aureus clones containing the toxic shock syndrome toxin 1 gene responsible for hospital- and community-acquired infections in France.  |  Durand, G., et al. 2006. J Clin Microbiol. 44: 847-53. PMID: 16517865
6. Prognostic relevance of AGR2 expression in breast cancer.  |  Fritzsche, FR., et al. 2006. Clin Cancer Res. 12: 1728-34. PMID: 16551856
7. Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients.  |  Innes, HE., et al. 2006. Br J Cancer. 94: 1057-65. PMID: 16598187
8. Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients.  |  Zhang, Y., et al. 2007. Prostate Cancer Prostatic Dis. 10: 293-300. PMID: 17457305
9. High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines.  |  Zhu, H., et al. 2007. Cancer Lett. 245: 303-14. PMID: 16517066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AGR2 Antibody (6C5) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-AGR2 Antibody (6C5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AGR2 Antibody (6C5) Specifications

Alternate Product Name: AGR2

Product Clone Name: 6C5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-176

Epitope Target: AGR2

Epitope Species: human

Product Reactivity/Detection: AGR2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for AGR2 Antibody (6C5): N/A

The preferred AGR2/3 antibody is AGR2/3 Antibody (C-7): sc-376653.