AGPS Antibody (B-9): sc-515671

AGPS Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects AGPS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AGPS, or alkyldihydroxyacetonephosphate synthase, is a crucial enzyme consisting of 658 amino acids that plays a vital role in glycerolipid metabolism and ether lipid biosynthesis. Anti-AGPS antibody (B-9) targets a protein localized to the inner aspect of the peroxisomal membrane, where AGPS functions as part of a heterotrimeric complex alongside GNPAT and a modified form of GNPAT. The structure of AGPS includes a single FAD-binding PCMH-type domain, which is essential for enzymatic activity, as AGPS utilizes FAD as a cofactor to synthesize alkyl-glycerone 3-phosphate and a long-chain acid anion from 1-acetyl-glycerone 3-phosphate and a long-chain alcohol. Defects in the gene encoding AGPS are linked to rhizomelic chondrodysplasia punctata type 3, a severe genetic disorder characterized by vertebral abnormalities, significant cognitive impairment, skin lesions, cataracts, and shortening of the humerus and femur. AGPS monoclonal antibody (B-9) serves as an invaluable tool for researchers studying AGPS implications in both normal physiology and disease states.

The preferred AGPS antibody is AGPS Antibody (A-2): sc-374201.