aggrecan Antibody (3H525): sc-70332
- aggrecan Antibody (3H525) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against human articular cartilage aggrecan
- recommended for detection of aggrecan of human origin by WB, IP, IF and IHC(P)
- See aggrecan (4F4): sc-33695 for aggrecan antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for aggrecan Antibody (3H525) for WB and IHC(P) applications. These reagents are now offered in bundles with aggrecan Antibody (3H525) (see ordering information below).
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Aggrecan Antibody (3H525) is a mouse monoclonal IgG1 antibody that detects aggrecan in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Aggrecan is a large chondroitin sulfate proteoglycan that plays a crucial role in maintaining the structural integrity and function of cartilage. Aggrecan (3H525) antibody targets proteins primarily located in the extracellular matrix of cartilage tissue, where aggrecan forms aggregates with hyaluronan and link proteins, creating a resilient and compressive network essential for the mechanical properties of hyaline cartilage. This structural arrangement allows aggrecan to withstand compressive forces, making aggrecan vital for joint function and mobility. Importantly, aggrecan degradation is often associated with various forms of inflammatory arthritis, leading to cartilage loss and joint dysfunction. Anti-aggrecan antibody (3H525) enables researchers to investigate aggrecan presence and distribution in pathological conditions, providing insights into the mechanisms underlying cartilage degradation and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
aggrecan Antibody (3H525) References:
- Structure and function of aggrecan. | Kiani, C., et al. 2002. Cell Res. 12: 19-32. PMID: 11942407
- Aggrecan, aging and assembly in articular cartilage. | Dudhia, J. 2005. Cell Mol Life Sci. 62: 2241-56. PMID: 16143826
- The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. | Roughley, P., et al. 2006. Eur Cell Mater. 11: 1-7; discussion 7. PMID: 16425147
- The different roles of aggrecan interaction domains. | Aspberg, A. 2012. J Histochem Cytochem. 60: 987-96. PMID: 23019016
- Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis. | Hanyecz, A., et al. 2014. Biomed Res Int. 2014: 942148. PMID: 24605340
- Structure, function, aging and turnover of aggrecan in the intervertebral disc. | Sivan, SS., et al. 2014. Biochim Biophys Acta. 1840: 3181-9. PMID: 25065289
- Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis. | Mort, JS., et al. 2016. BMC Musculoskelet Disord. 17: 89. PMID: 26891838
- Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity. | Krawetz, RJ., et al. 2022. Cell Death Dis. 13: 470. PMID: 35585042
- Analysis of Aggrecan Glycanation by Western Blot in Cell Culture. | Gramegna Tota, C., et al. 2023. Methods Mol Biol. 2619: 141-151. PMID: 36662468
- Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration. | Wang, C., et al. 2023. Adv Exp Med Biol. 1402: 69-82. PMID: 37052847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
aggrecan Antibody (3H525) | sc-70332 | 200 µg/ml | $316.00 | |||
aggrecan Antibody (3H525): m-IgG Fc BP-HRP Bundle | sc-539264 | 200 µg Ab; 10 µg BP | $354.00 | |||
aggrecan Antibody (3H525): m-IgG1 BP-HRP Bundle | sc-541363 | 200 µg Ab; 20 µg BP | $354.00 |