aggrecan Antibody (3H524): sc-70333

aggrecan Antibody (3H524) is a mouse monoclonal IgG1 antibody that detects aggrecan in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. aggrecan is a large chondroitin sulfate proteoglycan that plays a crucial role in maintaining the structural integrity and function of cartilage. aggrecan (3H524) antibody is primarily located in the extracellular matrix of cartilage tissue, where aggrecan forms aggregates with hyaluronan and link proteins, creating a resilient and compressive network essential for the mechanical properties of hyaline cartilage. This structural arrangement allows aggrecan to withstand compressive forces, making aggrecan vital for joint function and mobility. The degradation of aggrecan is often associated with various forms of inflammatory arthritis, leading to cartilage damage and loss, which underscores the significance of monitoring aggrecan levels in clinical settings. anti-aggrecan antibody (3H524) is an invaluable tool for researchers studying cartilage biology, joint diseases, and the underlying mechanisms of proteoglycan function in health and disease.

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aggrecan Antibody (3H524) References:

1. An ARGS-aggrecan assay for analysis in blood and synovial fluid.  |  Larsson, S., et al. 2014. Osteoarthritis Cartilage. 22: 242-9. PMID: 24361794
2. Aggrecan is required for growth plate cytoarchitecture and differentiation.  |  Lauing, KL., et al. 2014. Dev Biol. 396: 224-36. PMID: 25446537
3. Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.  |  Cikach, FS., et al. 2018. JCI Insight. 3: PMID: 29515038
4. Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells.  |  Hodax, JK., et al. 2019. PLoS One. 14: e0218399. PMID: 31206541
5. Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity.  |  Hayes, AJ. and Melrose, J. 2020. Biomolecules. 10: PMID: 32867198
6. Aggrecan: a new biomarker for acute type A aortic dissection.  |  König, KC., et al. 2021. Sci Rep. 11: 10371. PMID: 33990642
7. The relationship between the aggrecan VNTR polymorphism and its content in lumbar intervertebral discs.  |  Pękala, P., et al. 2023. Folia Morphol (Warsz). 82: 269-273. PMID: 35239182
8. Evaluation of aggrecan and adipokine levels in temporomandibular joint synovial fluid.  |  Bayındır, Ş., et al. 2022. J Craniomaxillofac Surg. 50: 432-438. PMID: 35491326
9. Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension.  |  van der Have, O., et al. 2023. Pulm Circ. 13: e12200. PMID: 36824691
10. Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix.  |  Empere, M., et al. 2023. Front Bioeng Biotechnol. 11: 1128587. PMID: 36937743

The preferred aggrecan antibody is aggrecan Antibody (4F4): sc-33695.