ADNP Antibody (F-5): sc-393377

ADNP Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects ADNP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ADNP antibody (F-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The activity-dependent neuroprotector (ADNP) protein, also known as activity-dependent neuroprotective protein, plays a critical role as a putative transcription factor, influencing normal growth and cancer proliferation. ADNP is a highly conserved gene responsive to vasoactive intestinal peptide (VIP) and is predominantly expressed in the brain, particularly in the cerebellum and cortex, where ADNP is essential for brain formation and embryonic development. Nuclear localization of ADNP enables regulation of gene expression, which is vital for neuronal survival and function. ADNP is also expressed in various tissues, including kidney, placenta, heart, skeletal muscle, and is notably upregulated in breast and colon cancer tissues. Research suggests that neuroprotection mediated by subpicomolar PACAP38 may involve ADNP expression, and elevated ADNP levels have been correlated with brain injuries, indicating a potential role in an endogenous compensatory mechanism.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ADNP Antibody (F-5) References:

1. From vasoactive intestinal peptide (VIP) through activity-dependent neuroprotective protein (ADNP) to NAP: a view of neuroprotection and cell division.  |  Gozes, I., et al. 2003. J Mol Neurosci. 20: 315-22. PMID: 14501014
2. Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus.  |  Furman, S., et al. 2005. Neurosci Lett. 373: 73-8. PMID: 15555780
3. The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury.  |  Gozes, I., et al. 2005. Curr Alzheimer Res. 2: 149-53. PMID: 15974912
4. The influence of the peptide NAP on Mac-1-deficient mice following closed head injury.  |  Zaltzman, R., et al. 2005. Peptides. 26: 1520-7. PMID: 16042992
5. Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase-activating polypeptide 38.  |  Li, M., et al. 2005. J Mol Neurosci. 27: 91-105. PMID: 16055949
6. Brain deficits associated with fetal alcohol exposure may be protected, in part, by peptides derived from activity-dependent neurotrophic factor and activity-dependent neuroprotective protein.  |  Sari, Y. and Gozes, I. 2006. Brain Res Rev. 52: 107-18. PMID: 16488478
7. Signaling involved in pituitary adenylate cyclase-activating polypeptide-stimulated ADNP expression.  |  Nakamachi, T., et al. 2006. Peptides. 27: 1859-64. PMID: 16564114
8. NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP).  |  Gozes, I., et al. 2005. CNS Drug Rev. 11: 353-68. PMID: 16614735

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADNP Antibody (F-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ADNP Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADNP Antibody (F-5) Specifications

Alternate Product Name: ADNP

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-138

Epitope Target: ADNP

Epitope Species: human

Product Reactivity/Detection: ADNP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ADNP Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent