AdipoR1 Antibody (D-9): sc-518030

AdipoR1 Antibody (D-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects AdipoR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AdipoR1 (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AdipoR1 plays a crucial role in mediating adiponectin effects, a hormone secreted by adipocytes that enhances glucose and lipid metabolism. AdipoR1, along with AdipoR2, is primarily located in liver and muscle tissues, where AdipoR1 regulates fatty acid oxidation and glucose uptake. These receptors are vital for maintaining metabolic homeostasis, being involved in signaling pathways that influence insulin sensitivity and body composition. AdipoR1 has a high affinity for globular adiponectin and a lower affinity for full-length adiponectin, selectively activating specific signaling cascades, including AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARα). AdipoR1 and AdipoR2 expression is significantly affected by physical training, which can enhance circulating adiponectin levels and improve insulin resistance, highlighting these receptors′ importance in metabolic health and potential therapeutic implications for obesity and diabetes.

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AdipoR1 Antibody (D-9) References:

1. Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice.  |  Blüher, M., et al. 2005. Biochem Biophys Res Commun. 329: 1127-32. PMID: 15752770
2. Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics.  |  Chen, MB., et al. 2005. J Clin Endocrinol Metab. 90: 3665-72. PMID: 15769985
3. Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.  |  Kaltenbach, S., et al. 2005. Int J Obes (Lond). 29: 760-5. PMID: 15824748
4. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.  |  Nilsson, L., et al. 2005. Biochem Biophys Res Commun. 331: 1120-6. PMID: 15882993
5. Adiponectin and adiponectin receptors.  |  Kadowaki, T. and Yamauchi, T. 2005. Endocr Rev. 26: 439-51. PMID: 15897298
6. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.  |  Blüher, M., et al. 2006. J Clin Endocrinol Metab. 91: 2310-6. PMID: 16551730
7. Improvement of insulin sensitivity after peroxisome proliferator-activated receptor-alpha agonist treatment is accompanied by paradoxical increase of circulating resistin levels.  |  Haluzik, MM., et al. 2006. Endocrinology. 147: 4517-24. PMID: 16740970
8. Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.  |  Morínigo, R., et al. 2006. Obes Surg. 16: 745-51. PMID: 16756736
9. AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.  |  Xu, H., et al. 2020. Nat Commun. 11: 5807. PMID: 33199780
10. Blocking Adipor1 enhances radiation sensitivity in Hepatoma Carcinoma Cells.  |  Liu, Y., et al. 2022. Arch Biochem Biophys. 718: 109152. PMID: 35183544
11. Schisandrin A from Schisandra chinensis Attenuates Ferroptosis and NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy through Mitochondrial Damage by AdipoR1 Ubiquitination.  |  Wang, X., et al. 2022. Oxid Med Cell Longev. 2022: 5411462. PMID: 35996380
12. Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.  |  Kobori, T., et al. 2024. Sci Rep. 14: 5701. PMID: 38459078

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AdipoR1 Antibody (D-9) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-AdipoR1 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AdipoR1 Antibody (D-9) Specifications

Alternate Product Name: AdipoR1

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 16-41

Epitope Target: AdipoR1

Epitope Species: human

Product Reactivity/Detection: AdipoR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for AdipoR1 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin