Adenosine A2A-R Antibody (F-10): sc-365235
- Adenosine A2A-R Antibody (F-10) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 331-412 mapping within a C-terminal cytoplasmic domain of Adenosine A2A-R of human origin
- recommended for detection of Adenosine A2A-R of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- also available conjugated to Alexa Fluor® 488 (sc-365235 AF488, 200 µg/ml) for IF, IHC(P) and FCM
- See Adenosine A2A-R (7F6-G5-A2): sc-32261 for Adenosine A2A-R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Adenosine A2A-R Antibody (F-10). This work is in progress.
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Adenosine A2A-R Antibody (F-10) is a mouse monoclonal IgM antibody that detects Adenosine A2A-R in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Adenosine A2A-R is a key member of the G protein-coupled receptor family, playing a vital role in mediating physiological responses such as coronary vasodilation and inflammatory process modulation. Adenosine A2A-R predominantly resides on the cell surface, where strategic positioning allows interaction with extracellular adenosine, influencing intracellular signaling pathways. This strategic location enables rapid responses to changes in adenosine levels, crucial during tissue injury or stress. Adenosine A2A-R′s interaction with various signaling molecules, including G proteins, highlights a significant role in regulating diverse biological functions, from neurotransmission to immune responses. Anti-Adenosine A2A-R antibody (F-10) serves as an essential tool for researchers exploring adenosine signaling mechanisms and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Adenosine A2A-R Antibody (F-10) References:
- Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation. | Borroto-Escuela, DO., et al. 2018. Front Neurosci. 12: 43. PMID: 29467608
- Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5'-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients. | Vogt, TJ., et al. 2018. Oncoimmunology. 7: e1452579. PMID: 30221045
- ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson's Disease. | Siokas, V., et al. 2021. J Clin Med. 10: PMID: 33498513
- Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy. | Liu, Y., et al. 2022. Adv Sci (Weinh). 9: e2104182. PMID: 35306759
- 7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells. | Fan, Y., et al. 2022. Ophthalmic Res. 65: 678-684. PMID: 35724635
- Adenosine-ADORA2A Promotes Ang-Induced Angiogenesis in Intrauterine Growth Restriction Placenta via the Stat3/Akt Pathway. | Wu, Z., et al. 2023. Arterioscler Thromb Vasc Biol. 43: e190-e209. PMID: 37051927
- Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer. | Shreenivas, A., et al. 2024. Int J Mol Sci. 25: PMID: 38731962
- Adenosine A2AR in viral immune evasion and therapy: unveiling new avenues for treating COVID-19 and AIDS. | Atif, M., et al. 2024. Mol Biol Rep. 51: 894. PMID: 39115571
- Brain Specific RagA Overexpression Triggers Depressive-Like Behaviors in Mice via Activating ADORA2A Signaling Pathway. | Zhao, J., et al. 2024. Adv Sci (Weinh). 11: e2404188. PMID: 39373701
- Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A. | Le, F., et al. 1996. Biochem Biophys Res Commun. 223: 461-7. PMID: 8670304
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine A2A-R Antibody (F-10) | sc-365235 | 200 µg/ml | $316.00 | |||
Adenosine A2A-R Antibody (F-10) Alexa Fluor® 488 | sc-365235 AF488 | 200 µg/ml | $344.00 |