ADAR3 Antibody (3.591): sc-73410
- ADAR3 Antibody (3.591) is a mouse monoclonal IgG κ ADAR3 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to N terminal amino acids 2-101 of ADAR3 of human origin
- ADAR3 Antibody (3.591) is recommended for detection of native and recombinant ADAR3 of mouse, rat and human origin by WB and IP; non cross-reactive with other members of the ADAR family
- Anti-ADAR3 Antibody (3.591) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ADAR3 Antibody (3.591) for WB applications. This reagent is now offered in a bundle with ADAR3 Antibody (3.591) (see ordering information below).
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ADAR3 Antibody (3.591) is a mouse monoclonal IgG antibody that detects ADAR3 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ADAR3 antibody (3.591) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. ADAR3 protein plays a crucial role in RNA editing, specifically in the modification of adenosine residues to inosine within double-stranded RNA structures, which is essential for the regulation of gene expression and the generation of protein diversity. This editing process can lead to changes in the coding potential of mRNA transcripts, ultimately influencing cellular functions and responses. The ADAR family, including ADAR3, is characterized by a central series of double-stranded RNA-binding motifs and a C-terminal catalytic domain, which are critical for enzymatic activity. Understanding ADAR3 function and interactions with other RNA molecules is important for elucidating its role in neurological processes and potential implications in various diseases, including neurological disorders and cancers.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADAR3 Antibody (3.591) References:
- Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. | Higuchi, M., et al. 2000. Nature. 406: 78-81. PMID: 10894545
- Substrate recognition by ADAR1 and ADAR2. | Wong, SK., et al. 2001. RNA. 7: 846-58. PMID: 11421361
- ADAR2 A-->I editing: site selectivity and editing efficiency are separate events. | Källman, AM., et al. 2003. Nucleic Acids Res. 31: 4874-81. PMID: 12907730
- Modulation of RNA editing by functional nucleolar sequestration of ADAR2. | Sansam, CL., et al. 2003. Proc Natl Acad Sci U S A. 100: 14018-23. PMID: 14612560
- Structure and sequence determinants required for the RNA editing of ADAR2 substrates. | Dawson, TR., et al. 2004. J Biol Chem. 279: 4941-51. PMID: 14660658
- ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. | Vitali, P., et al. 2005. J Cell Biol. 169: 745-53. PMID: 15939761
- Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. | Macbeth, MR., et al. 2005. Science. 309: 1534-9. PMID: 16141067
- Altered RNA editing in mice lacking ADAR2 autoregulation. | Feng, Y., et al. 2006. Mol Cell Biol. 26: 480-8. PMID: 16382140
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAR3 Antibody (3.591) | sc-73410 | 200 µg/ml | $322.00 | |||
ADAR3 Antibody (3.591): m-IgG Fc BP-HRP Bundle | sc-525698 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADAR3 Antibody (3.591) AC | sc-73410 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ADAR3 Antibody (3.591) HRP | sc-73410 HRP | 200 µg/ml | $322.00 | |||
ADAR3 Antibody (3.591) FITC | sc-73410 FITC | 200 µg/ml | $336.00 | |||
ADAR3 Antibody (3.591) PE | sc-73410 PE | 200 µg/ml | $349.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 488 | sc-73410 AF488 | 200 µg/ml | $364.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 546 | sc-73410 AF546 | 200 µg/ml | $364.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 594 | sc-73410 AF594 | 200 µg/ml | $364.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 647 | sc-73410 AF647 | 200 µg/ml | $364.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 680 | sc-73410 AF680 | 200 µg/ml | $364.00 | |||
ADAR3 Antibody (3.591) Alexa Fluor® 790 | sc-73410 AF790 | 200 µg/ml | $364.00 |