ADAMTS-2 Antibody (H-4): sc-398556

ADAMTS-2 Antibody (H-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects ADAMTS-2 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAMTS-2, a member of the ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) family, plays a crucial role in collagen biosynthesis by cleaving the propeptides of Collagen Types I and II, which is essential for proper assembly of collagen fibrils. This function is particularly important as collagen is a primary structural protein in various tissues, contributing to their strength and integrity. ADAMTS-2 is secreted and predominantly associated with the extracellular matrix, with highest expression levels found in skin, bone, tendon, and aorta. Additionally, defects in ADAMTS-2 are linked to Ehlers-Danlos syndrome type VIIC, a genetic disorder that leads to significant skin fragility and joint hypermobility, highlighting ADAMTS-2′s importance in connective tissue health. Anti-ADAMTS-2 antibody (H-4) is an invaluable tool for researchers studying ADAMTS-2′s roles in both normal physiological processes and pathological conditions.

The preferred ADAMTS-2 antibody is ADAMTS-2 Antibody (F-4): sc-393562.