ADAM22 Antibody (F-3): sc-515300

ADAM22 Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects ADAM22 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAM22 is a member of the ADAM (a disintegrin and metalloprotease) protein family, which consists of over 30 membrane-anchored, glycosylated, zinc-dependent proteases that are crucial for various biological processes, including cell-cell interactions and signaling pathways. ADAM22 is predominantly expressed in the brain, where ADAM22 plays a significant role in synaptic function and neuronal communication, making ADAM22 essential for cognitive processes and neurodevelopment. The structure of ADAM22 includes several functional domains, such as a metalloprotease domain and a disintegrin domain, which facilitate ADAM22 interactions with integrins and other cell surface proteins, thereby influencing cell adhesion and migration. Notably, ADAM22 and ADAM23 share structural similarities and are both implicated in the modulation of synaptic plasticity, highlighting their importance in neurological health and disease. The genes encoding ADAM22 and ADAM23 are located on chromosomes 7q21 and 2q33, respectively, underscoring their evolutionary conservation and functional significance across species.

The preferred ADAM22 antibody is ADAM22 Antibody (C-2): sc-373931.