ADAM15 Antibody (D-5): sc-365752
- ADAM15 Antibody (D-5) is a mouse monoclonal IgG1 κ ADAM15 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 561-620 of ADAM15 of human origin
- ADAM15 Antibody (D-5) is recommended for detection of ADAM15 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ADAM15 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ADAM15 Antibody (D-5) for WB applications. These reagents are now offered in bundles with ADAM15 Antibody (D-5) (see ordering information below).
ADAM15 Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects ADAM15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAM15 Antibody (D-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ADAM15, also known as metargidin, is a crucial member of the ADAM family, which consists of over 30 membrane-anchored, glycosylated, zinc-dependent proteases that play significant roles in cell-cell interactions and the cell-matrix interface. ADAM15 is involved in processes such as fertilization, muscle fusion, and the secretion of tumor necrosis factor alpha, as well as modulating the neurogenic functions of Notch and Delta signaling pathways. Structurally, ADAM15 is an 814 amino acid plasma membrane protein characterized by a unique RGD tripeptide sequence that facilitates binding to integrins alphaV/beta3 and alpha5/beta1, which is essential for mediating cell adhesion and signaling. The presence of multiple functional domains, including a metalloprotease domain and a disintegrin domain, underscores ADAM15′s versatility in various biological processes, making ADAM15 a vital target for research in cell biology and therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADAM15 Antibody (D-5) References:
- Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review). | Stone, AL., et al. 1999. J Protein Chem. 18: 447-65. PMID: 10449042
- The ADAM gene family: surface proteins with adhesion and protease activity. | Primakoff, P. and Myles, DG. 2000. Trends Genet. 16: 83-7. PMID: 10652535
- ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. | Wolfsberg, TG., et al. 1995. J Cell Biol. 131: 275-8. PMID: 7593158
- Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. | Krätzschmar, J., et al. 1996. J Biol Chem. 271: 4593-6. PMID: 8617717
- Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. | Nath, D., et al. 1999. J Cell Sci. 112 (Pt 4): 579-87. PMID: 9914169
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAM15 Antibody (D-5) | sc-365752 | 200 µg/ml | $322.00 | |||
ADAM15 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-529455 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADAM15 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-522352 | 200 µg Ab, 40 µg BP | $361.00 | |||
ADAM15 Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-543526 | 200 µg Ab; 20 µg BP | $361.00 | |||
ADAM15 Antibody (D-5) AC | sc-365752 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ADAM15 Antibody (D-5) HRP | sc-365752 HRP | 200 µg/ml | $322.00 | |||
ADAM15 Antibody (D-5) FITC | sc-365752 FITC | 200 µg/ml | $336.00 | |||
ADAM15 Antibody (D-5) PE | sc-365752 PE | 200 µg/ml | $349.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 488 | sc-365752 AF488 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 546 | sc-365752 AF546 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 594 | sc-365752 AF594 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 647 | sc-365752 AF647 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 680 | sc-365752 AF680 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) Alexa Fluor® 790 | sc-365752 AF790 | 200 µg/ml | $364.00 | |||
ADAM15 Antibody (D-5) B | sc-365752 B | 200 µg/ml | $326.00 |