ACTL7B Antibody (G-2): sc-514196

ACTL7B Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects ACTL7B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACTL7B, also known as actin-like 7B, is a crucial member of the ARP family of actin-related proteins, playing a significant role in spindle orientation, nuclear migration, and chromatin remodeling, which are essential processes for proper cell division and function. ACTL7B is primarily localized in the cytoplasm and is notably expressed in the testis and prostate, highlighting its potential involvement in reproductive biology. With a length of 415 amino acids, ACTL7B is encoded by a gene situated in a head-to-head orientation with the familial dysautonomia candidate region on chromosome 9; however, ACTL7B is not implicated in the pathogenesis of this genetic disorder. ACTL7B exhibits high sequence similarity with ACTL7A, sharing 88% sequence identity between human and mouse proteins, and contains critical phosphorylation sites, including one for protein kinase C and another for cAMP/cGMP-dependent kinases, which are vital for regulating its activity and interactions. Anti-ACTL7B antibody (G-2) is an invaluable tool for researchers investigating the dynamics of actin-related processes and their implications in various biological contexts.

The preferred ACTL7B antibody is ACTL7B Antibody (F-1): sc-398446.