ACTL7B Antibody (F-1): sc-398446

ACTL7B Antibody (F-1) is a mouse monoclonal IgG3 antibody that detects ACTL7B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ACTL7B antibody (F-1) is available as a non-conjugated format. ACTL7B, also known as actin-like 7B, is a crucial member of the actin-related protein (ARP) family, characterized by its actin fold structure, which plays a significant role in essential cellular processes such as spindle orientation, nuclear migration, and chromatin remodeling. ACTL7B is primarily localized in the cytoplasm and is notably expressed in the testis and prostate, where ACTL7B contributes to cellular dynamics and organization. With a length of 415 amino acids, ACTL7B is encoded by a gene situated in a head-to-head orientation with the familial dysautonomia candidate region on chromosome 9; however, ACTL7B is not implicated in the pathogenesis of this genetic disorder. ACTL7B exhibits a high degree of sequence similarity with ACTL7A, sharing 88% sequence identity between human and mouse proteins, and contains critical phosphorylation sites, including one for protein kinase C and another for cAMP/cGMP-dependent kinases, which are vital for its regulatory functions.

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ACTL7B Antibody (F-1) References:

1. Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31.  |  Chadwick, BP., et al. 1999. Genomics. 58: 302-9. PMID: 10373328
2. Actin-related proteins.  |  Schafer, DA. and Schroer, TA. 1999. Annu Rev Cell Dev Biol. 15: 341-63. PMID: 10611965
3. Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells.  |  Tanaka, H., et al. 2003. Biol Reprod. 69: 475-82. PMID: 12672658
4. Genomic structure and promoter activity of the testis haploid germ cell-specific intronless genes, Tact1 and Tact2.  |  Hisano, M., et al. 2003. Mol Reprod Dev. 65: 148-56. PMID: 12704725
5. Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells.  |  Hisano, M., et al. 2003. Nucleic Acids Res. 31: 4797-804. PMID: 12907721

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACTL7B Antibody (F-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ACTL7B Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACTL7B Antibody (F-1) Specifications

Alternate Product Name: ACTL7B

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 200-215

Epitope Target: ACTL7B

Epitope Species: human

Product Reactivity/Detection: ACTL7B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ACTL7B Antibody (F-1): P: Blocking Peptide