ACTH Antibody (HAT C22): sc-69902
- ACTH Antibody (HAT C22) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 18-39 of ACTH of human origin
- recommended for detection of POMC and the processed active peptide ACTH of human origin by WB, IP, IF and ELISA
- See ACTH/CLIP (F-3): sc-373878 for ACTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACTH Antibody (HAT C22). This work is in progress.
QUICK LINKS
ACTH Antibody (HAT C22) is a mouse monoclonal IgG1 antibody specifically designed to detect adrenocorticotropic hormone (ACTH), also known as corticotropin, a 39-amino-acid peptide derived from pro-opiomelanocortin (POMC). Targeting amino acids 18-39 of human ACTH, anti-ACTH antibody (HAT C22) effectively detects both POMC and the processed active peptide ACTH in human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) techniques. ACTH plays a crucial role in stimulating the adrenal cortex to secrete cortisol in response to biological stress, interacting specifically with the melanocortin 2 receptor (MC2R) and its accessory protein MRAP (Melanocortin 2 Receptor Accessory Protein). These interactions are vital for regulating cortisol synthesis, which affects metabolism, immune response, and stress adaptation. Additionally, ACTH can influence other melanocortin receptors, impacting processes like pigmentation and energy homeostasis. Mutations in the POMC gene can lead to POMC deficiency, characterized by adrenal insufficiency, obesity, and altered pigmentation such as red hair. Understanding the interactions and functions of ACTH is essential for studying disorders like Cushing′s disease and Addison′s disease. ACTH (HAT C22) monoclonal antibody provides researchers with a reliable tool to investigate the expression and interactions of ACTH, facilitating advancements in endocrinology and neurobiology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTH Antibody (HAT C22) | sc-69902 | 100 µg/ml | $322.00 |