ACSVL4 Antibody (H-6): sc-393309

ACSVL4 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACSVL4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACSVL4 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACSVL4 plays a crucial role in fatty acid metabolism as a member of the acyl-coenzyme A synthetase (ACS) family, which is responsible for catalyzing the initial reaction in the activation of fatty acids. Specifically, ACSVL4 is involved in the transport and activation of long-chain and very long-chain fatty acids, which are essential for various cellular processes, including energy production and membrane synthesis. ACSVL4′s unique expression patterns in key organs such as adipose tissue, liver, heart, and kidney highlight its importance in maintaining metabolic homeostasis. Additionally, ACSVL4 interacts with other proteins within the solute carrier family, facilitating the translocation of fatty acids across the plasma membrane, thereby underscoring its critical function in lipid metabolism and cellular energy balance.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ACSVL4 Antibody (H-6) References:

1. Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.  |  Abumrad, N., et al. 1999. Biochim Biophys Acta. 1441: 4-13. PMID: 10526223
2. Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target.  |  Martin, G., et al. 2000. J Biol Chem. 275: 12612-8. PMID: 10777552
3. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.  |  Martin, G., et al. 2000. Genomics. 66: 296-304. PMID: 10873384
4. Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans.  |  Binnert, C., et al. 2000. Am J Physiol Endocrinol Metab. 279: E1072-9. PMID: 11052962
5. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4.  |  Milger, K., et al. 2006. J Cell Sci. 119: 4678-88. PMID: 17062637
6. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.  |  Watkins, PA., et al. 2007. J Lipid Res. 48: 2736-50. PMID: 17762044
7. Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.  |  Krammer, J., et al. 2011. Int J Med Sci. 8: 599-614. PMID: 22022213
8. Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle.  |  Jeppesen, J., et al. 2012. PLoS One. 7: e29391. PMID: 22235293
9. Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression.  |  Hutchinson, KA., et al. 2020. Reprod Sci. 27: 1909-1919. PMID: 32519158
10. DHA Improves neurodevelopmental abnormalities in offspring of gestational diabetes mellitus patients via the PPAR-γ/FATP4 pathway.  |  Jiang, Y., et al. 2025. Biochem Pharmacol. 232: 116726. PMID: 39716642
11. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein.  |  Schaffer, JE. and Lodish, HF. 1994. Cell. 79: 427-36. PMID: 7954810
12. A family of fatty acid transporters conserved from mycobacterium to man.  |  Hirsch, D., et al. 1998. Proc Natl Acad Sci U S A. 95: 8625-9. PMID: 9671728

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACSVL4 Antibody (H-6) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-ACSVL4 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACSVL4 Antibody (H-6) Specifications

Alternate Product Name: ACSVL4

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 582-609

Epitope Target: ACSVL4

Epitope Species: human

Product Reactivity/Detection: ACSVL4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for ACSVL4 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin