ACSS1 Antibody (D-7): sc-377149

ACSS1 Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects ACSS1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ACSS1 Antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACSS1, also known as acyl-CoA synthetase short-chain family member 1, is a 689 amino acid enzyme localized in the mitochondrial matrix and is a member of the ATP-dependent AMP-binding enzyme family. ACSS1 plays a crucial role in cellular metabolism by catalyzing the ATP-dependent conversion of acetate and coenzyme A to acetyl-CoA, which is essential for the oxidation of acetate in the tricarboxylic acid cycle, thereby contributing to energy production in cardiac tissues. ACSS1 is expressed as two alternatively spliced isoforms and is encoded by a gene located on chromosome 20, which comprises approximately 2% of the human genome and contains over 600 genes linked to various diseases, including Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis. ACSS1′s ability to facilitate the conversion of acetate to acetyl-CoA underscores its importance in metabolic pathways, particularly in conditions where energy substrates are limited, making ACSS1 a significant target for research in metabolic disorders and cardiac function.

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ACSS1 Antibody (D-7) References:

1. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.  |  Fujino, T., et al. 2001. J Biol Chem. 276: 11420-6. PMID: 11150295
2. Does PRNP gene control the clinical and pathological phenotype of human spongiform transmissible encephalopathies?  |  Masullo, C. and Macchi, G. 2001. Clin Neuropathol. 20: 19-25. PMID: 11220690
3. Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies.  |  Collins, S., et al. 2001. J Clin Neurosci. 8: 387-97. PMID: 11535002
4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.  |  Nakajima, D., et al. 2002. DNA Res. 9: 99-106. PMID: 12168954
5. Early pattern of epilepsy in the ring chromosome 20 syndrome.  |  Ville, D., et al. 2006. Epilepsia. 47: 543-9. PMID: 16529619
6. Trisomy 20 mosaicism and nonmosaic trisomy 20: a report of 2 cases.  |  Joó, JG., et al. 2006. J Reprod Med. 51: 209-12. PMID: 16674019
7. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis.  |  Lundwall, A. 2007. Asian J Androl. 9: 540-4. PMID: 17589793
8. Ring chromosome 20 syndrome without deletions of the subtelomeric and CHRNA4--KCNQ2 genes loci.  |  Elghezal, H., et al. 2007. Eur J Med Genet. 50: 441-5. PMID: 17851150
9. The prion diseases.  |  Prusiner, SB. 1998. Brain Pathol. 8: 499-513. PMID: 9669700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACSS1 Antibody (D-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ACSS1 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACSS1 Antibody (D-7) Specifications

Alternate Product Name: ACSS1

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 67-99

Epitope Target: ACSS1

Epitope Species: human

Product Reactivity/Detection: ACSS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ACSS1 Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin