ACSL4 Antibody (F-4): sc-365230

ACSL4 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACSL4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ACSL4 (F-4) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. ACSL4, a member of the acyl-CoA synthetase family, plays a crucial role in lipid metabolism by catalyzing the conversion of long-chain fatty acids into acyl-CoA derivatives, which are essential for cellular lipid synthesis and energy production through β-oxidation. ACSL4 is predominantly localized in mitochondria, microsomes, and peroxisomes, highlighting ACSL4′s importance in cellular energy homeostasis and lipid biosynthesis. ACSL4 is particularly abundant in steroidogenic tissues, where ACSL4 may influence female fertility and uterine prostaglandin production, underscoring potential implications in reproductive health. Anti-ACSL4 antibody (F-4) serves as a valuable tool for researchers studying metabolic pathways, particularly given ACSL4′s specialized function in utilizing specific fatty acids like arachidonate.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ACSL4 Antibody (F-4) References:

1. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.  |  Li, Y., et al. 2019. Cell Death Differ. 26: 2284-2299. PMID: 30737476
2. ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway.  |  Chen, J., et al. 2021. Cancer Lett. 502: 154-165. PMID: 33340617
3. Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways.  |  Chen, Y., et al. 2023. Diabetes. 72: 389-404. PMID: 36367849
4. ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers.  |  Yang, Y., et al. 2022. Cancers (Basel). 14: PMID: 36497375
5. Calycosin decreases cerebral ischemia/reperfusion injury by suppressing ACSL4-dependent ferroptosis.  |  Liu, H., et al. 2023. Arch Biochem Biophys. 734: 109488. PMID: 36516890
6. ACSL4: biomarker, mediator and target in quadruple negative breast cancer.  |  Monaco, ME. 2023. Oncotarget. 14: 563-575. PMID: 37306503
7. ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma.  |  Chen, P., et al. 2023. Int Immunopharmacol. 122: 110629. PMID: 37451020
8. STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.  |  Gao, L., et al. 2023. Mol Ther. 31: 3084-3103. PMID: 37533255
9. EGCG attenuated acute myocardial infarction by inhibiting ferroptosis via miR-450b-5p/ACSL4 axis.  |  Yu, Q., et al. 2023. Phytomedicine. 119: 154999. PMID: 37597361
10. Vitamin D Attenuates Ulcerative Colitis by Inhibiting ACSL4-Mediated Ferroptosis.  |  Gao, S., et al. 2023. Nutrients. 15: PMID: 38004239

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACSL4 Antibody (F-4) has 87 citations in a variety of scientific publications.

Primary antibodies like Anti-ACSL4 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACSL4 Antibody (F-4) Specifications

Alternate Product Name: ACSL4

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 623-675

Epitope Target: ACSL4

Epitope Species: human

Product Reactivity/Detection: short isoform and long isoform of ACSL4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 87 citations in various scientific publications

Available Conjugates/Forms for ACSL4 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred ACSL4 antibody is ACSL4 Antibody (A-5): sc-271800.