ACP1α/β Antibody (B-2): sc-398459

ACP1α/β Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects ACP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACP1, or red cell acid phosphatase, plays a crucial role in regulating intracellular concentrations of flavin coenzymes, which are vital for various metabolic processes and maintaining cellular homeostasis. ACP1 is a genetically polymorphic, cytoplasmic low-molecular-weight flavin mononucleotide phosphatase that catalyzes the transfer of phosphate from phosphate ester substrates to suitable acceptor alcohols, such as methanol and glycerol. The human ACP1 gene is located on chromosome 2p25 and encodes two isozymes, Bf (alpha) and Bs (beta), which are both 157 amino acids in length but differ in sequence over a 34-residue segment, suggesting variations in substrate specificity. Both isoforms are not glycosylated, which may influence functional properties and interactions within the cell. ACP1′s ability to modulate flavin coenzyme levels underscores importance in metabolic regulation and potential implications in various diseases, making anti-ACP1 antibody (B-2) an essential tool for researchers studying these pathways.

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ACP1α/β Antibody (B-2) References:

1. Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress-A theoretical perspective.  |  Greene, LS., et al. 2000. Am J Hum Biol. 12: 688-701. PMID: 11534062
2. Analysis of the ACP1 gene product: classification as an FMN phosphatase.  |  Fuchs, KR., et al. 1992. Biochem Biophys Res Commun. 189: 1598-605. PMID: 1336375
3. Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms.  |  Nicotra, M., et al. 2007. Am J Reprod Immunol. 58: 1-10. PMID: 17565542
4. Skin testing correlates negatively with high-activity ACP1 *B/*C genotype.  |  Greco, E., et al. 2008. Int Arch Allergy Immunol. 145: 48-53. PMID: 17703100
5. p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁.  |  Gloria-Bottini, F., et al. 2012. Med Sci Monit. 18: CR712-5. PMID: 23197232
6. Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.  |  Wade, F., et al. 2015. J Pathol. 237: 482-94. PMID: 26213100
7. The effect of ACP1, ADA6 and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis.  |  Gloria-Bottini, F., et al. 2016. Arch Gynecol Obstet. 293: 399-402. PMID: 26216523
8. Allergy and Uterine Leiomyomas: Cooperative Interaction with ACP1 Genetic Polymorphism.  |  Gloria-Bottini, F., et al. 2015. J Reprod Infertil. 16: 199-202. PMID: 27110517
9. Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.  |  Li, J., et al. 2017. J Psychiatr Res. 94: 54-61. PMID: 28668716
10. Dissecting the Significance of Acid Phosphatase 1 Gene Alterations in Prostate Cancer.  |  Abdallah, N., et al. 2024. JCO Precis Oncol. 8: e2400444. PMID: 39348661

The preferred ACP1 antibody is ACP1 Antibody (D-3): sc-390190.