ACP1α Antibody (A-2): sc-393280
- ACP1α Antibody (A-2) is a mouse monoclonal IgG2a κ ACP1α antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 60-79 within an internal region of ACP1α of human origin
- recommended for detection of ACP1α of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ACP1α Antibody (A-2) for WB applications. These reagents are now offered in bundles with ACP1α Antibody (A-2) (see ordering information below).
ACP1α Antibody (A-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects the ACP1 alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ACP1α antibody (A-2) is available as the non-conjugated form. ACP1α (A-2) monoclonal antibody recognizes a protein that plays a crucial role in cellular metabolism by catalyzing the hydrolysis of phosphate esters, which is vital for maintaining cellular energy balance and signaling pathways. This enzyme, also known as red cell acid phosphatase, is involved in the regulation of intracellular concentrations of flavin coenzymes, which are essential for various biochemical reactions. The human ACP1 gene, located on chromosome 2p25, encodes two isozymes, ACP1-alpha and ACP1-beta, both of which consist of 157 amino acids but differ in a specific 34-residue segment that influences their substrate specificity. These isozymes are not glycosylated, which may affect their functional properties and interactions within the cell. Understanding the function and regulation of ACP1 alpha is important for elucidating its role in metabolic disorders and potential therapeutic targets.
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ACP1α Antibody (A-2) References:
- Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase. | Wo, YY., et al. 1992. J Biol Chem. 267: 10856-65. PMID: 1587862
- Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles. | Dissing, J. and Johnsen, AH. 1992. Biochim Biophys Acta. 1121: 261-8. PMID: 1627603
- Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele. | Dissing, J., et al. 1991. J Biol Chem. 266: 20619-25. PMID: 1939112
- Phenotypic variation in the phosphotransferase activity of human red cell acid phosphatase (ACP1). | Golden, VL. and Sensabaugh, GF. 1986. Hum Genet. 72: 340-3. PMID: 3009301
- Human red cell acid phosphatase (ACP1): evidence for differences in the primary structure of the two isozymes encoded by the ACP1*B allele. | Dissing, J. and Sensabaugh, GF. 1987. Biochem Genet. 25: 919-27. PMID: 3450278
- Exon structure at the human ACP1 locus supports alternative splicing model for f and s isozyme generation. | Lazaruk, KD., et al. 1993. Biochem Biophys Res Commun. 196: 440-6. PMID: 8216326
- Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. | Bryson, GL., et al. 1995. Genomics. 30: 133-40. PMID: 8586411
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACP1α Antibody (A-2) | sc-393280 | 200 µg/ml | $316.00 | |||
ACP1α Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-538177 | 200 µg Ab; 10 µg BP | $354.00 | |||
ACP1α Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-535739 | 200 µg Ab; 40 µg BP | $354.00 | |||
ACP1α Antibody (A-2): m-IgG2a BP-HRP Bundle | sc-548226 | 200 µg Ab; 10 µg BP | $354.00 | |||
ACP1α (A-2) Neutralizing Peptide | sc-393280 P | 100 µg/0.5 ml | $68.00 |