ACOT7 Antibody (C-2): sc-376808
- ACOT7 Antibody (C-2) is a mouse monoclonal IgG1 κ ACOT7 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 81-380 mapping at the C-terminus of ACOT7 of human origin
- ACOT7 Antibody (C-2) is recommended for detection of ACOT7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ACOT7 Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ACOT7 Antibody (C-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with ACOT7 Antibody (C-2) (see ordering information below).
ACOT7 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACOT7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-ACOT7 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACOT7, also known as brain acyl-CoA hydrolase (BACH), is a crucial enzyme that plays a significant role in lipid metabolism by catalyzing the hydrolysis of acyl-CoA to produce coenzyme A and free fatty acids. This enzymatic activity maintains the balance of fatty acids and acyl-CoAs within cells, essential for various cellular processes, including energy production and membrane synthesis. ACOT7 exists in six alternatively spliced isoforms that localize to either the cytoplasm or mitochondria, functioning as a homodimer with two acyl coenzyme A hydrolase domains. ACOT7 functions are particularly important for brain physiology, and decreased ACOT7 expression has been linked to mesial temporal lobe epilepsy, a condition characterized by recurrent seizures. Using ACOT7 (C-2) monoclonal antibody in research can provide insights into the regulatory mechanisms of fatty acid metabolism and their implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACOT7 Antibody (C-2) References:
- Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. | Yamada, J., et al. 1999. J Biochem. 126: 1013-9. PMID: 10578051
- Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. | Kuramochi, Y., et al. 2002. Brain Res Mol Brain Res. 98: 81-92. PMID: 11834298
- Human brain acyl-CoA hydrolase isoforms encoded by a single gene. | Yamada, J., et al. 2002. Biochem Biophys Res Commun. 299: 49-56. PMID: 12435388
- Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. | Yang, JW., et al. 2004. Amino Acids. 27: 269-75. PMID: 15592755
- Long-chain acyl-CoA hydrolase in the brain. | Yamada, J. 2005. Amino Acids. 28: 273-8. PMID: 15731883
- A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. | Hunt, MC., et al. 2005. J Lipid Res. 46: 2029-32. PMID: 16103133
- Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. | Serek, R., et al. 2006. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62: 133-5. PMID: 16511283
- Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. | Hunt, MC., et al. 2006. FASEB J. 20: 1855-64. PMID: 16940157
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACOT7 Antibody (C-2) | sc-376808 | 200 µg/ml | $322.00 | |||
ACOT7 Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-526052 | 200 µg Ab; 10 µg BP | $361.00 | |||
ACOT7 Antibody (C-2) AC | sc-376808 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ACOT7 Antibody (C-2) HRP | sc-376808 HRP | 200 µg/ml | $322.00 | |||
ACOT7 Antibody (C-2) FITC | sc-376808 FITC | 200 µg/ml | $336.00 | |||
ACOT7 Antibody (C-2) PE | sc-376808 PE | 200 µg/ml | $349.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 488 | sc-376808 AF488 | 200 µg/ml | $364.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 546 | sc-376808 AF546 | 200 µg/ml | $364.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 594 | sc-376808 AF594 | 200 µg/ml | $364.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 647 | sc-376808 AF647 | 200 µg/ml | $364.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 680 | sc-376808 AF680 | 200 µg/ml | $364.00 | |||
ACOT7 Antibody (C-2) Alexa Fluor® 790 | sc-376808 AF790 | 200 µg/ml | $364.00 |