Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145): sc-65759

AChRγ Antibody (145) is a rat monoclonal IgG2a antibody that detects AChR gamma of Torpedo origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-AChR gamma antibody (145) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AChR gamma, consisting of 517 amino acids, is a crucial component of the nicotinic acetylcholine receptor family, which is essential for fast synaptic transmission in the neuromuscular junction. AChR gamma plays a significant role in ligand binding and neuromuscular organogenesis, facilitating the binding of acetylcholine and the subsequent ion flow through the receptor′s transmembrane pore. Proper functioning of AChR gamma is vital, as mutations in the gene encoding AChR gamma can lead to severe developmental disorders such as Escobar syndrome and a lethal form of multiple pterygium syndrome. Using AChR gamma (145) monoclonal antibody in research can provide insights into the mechanisms of synaptic transmission and the implications of genetic mutations affecting neuromuscular function.

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Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145) References:

1. Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy.  |  Baenziger, JE., et al. 1992. Biophys J. 62: 64-6. PMID: 1600101
2. Ligand-gated ion channels in the brain: the amino acid receptor superfamily.  |  Betz, H. 1990. Neuron. 5: 383-92. PMID: 1698394
3. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel.  |  Alkondon, M., et al. 1988. J Pharmacol Exp Ther. 245: 543-56. PMID: 2452874
4. Neurotransmitter action: opening of ligand-gated ion channels.  |  Unwin, N. 1993. Cell. 72 Suppl: 31-41. PMID: 7679054
5. The diversity of neuronal nicotinic acetylcholine receptors.  |  Sargent, PB. 1993. Annu Rev Neurosci. 16: 403-43. PMID: 7681637
6. Quantal release of neurotransmitter and long-term potentiation.  |  Stevens, CF. 1993. Cell. 72 Suppl: 55-63. PMID: 8094037
7. The role of NMDA receptors in information processing.  |  Daw, NW., et al. 1993. Annu Rev Neurosci. 16: 207-22. PMID: 8460891
8. Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.  |  Ramirez-Latorre, J., et al. 1996. Nature. 380: 347-51. PMID: 8598930

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145) Specifications

Alternate Product Name: AChRγ

Product Clone Name: 145

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: AChR

Epitope Species: Torpedo

Product Reactivity/Detection: nicotinic AChRγ

Species Reactivity/Detection: Torpedo

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin