Nicotinic Acetylcholine Receptor delta/CHRND Antibody (140): sc-65808
- Nicotinic Acetylcholine Receptor delta/CHRND Antibody (140) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRδ of Torpedo origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor delta/CHRND Antibody (140). This work is in progress.
AChRδ Antibody (140) is a rat monoclonal IgG1 antibody that detects AChRδ in Torpedo species through applications such as western blotting (WB) and immunofluorescence (IF). AChRδ, also known as CMS2A, FCCMS, SCCMS, or CHRND, is a 517 amino acid multi-pass membrane protein that plays a crucial role in neuromuscular transmission by forming part of the nicotinic acetylcholine receptor complex. This receptor is essential for muscle contraction, as AChRδ mediates fast synaptic transmission at the neuromuscular junction by allowing cation influx upon acetylcholine binding. Proper functioning of AChRδ is vital, as mutations or dysfunctions are associated with severe conditions such as lethal type multiple pterygium syndrome and congenital myasthenic syndromes, including slow-channel type and fast-channel type. Localization of AChRδ at the postsynaptic membrane ensures strategic positioning to respond to neurotransmitter release, facilitating effective communication between nerve and muscle cells. Anti-AChRδ antibody (140) serves as an invaluable tool for researchers studying these critical pathways and the underlying mechanisms of neuromuscular disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor delta/CHRND Antibody (140) | sc-65808 | 200 µg/ml | $316.00 |