Nicotinic Acetylcholine Receptor delta/CHRND Antibody (138): sc-65806
- Nicotinic Acetylcholine Receptor delta/CHRND Antibody (138) is a rat monoclonal IgM provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRδ of Torpedo origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor delta/CHRND Antibody (138). This work is in progress.
AChRδ Antibody (138) is a rat monoclonal IgM antibody that detects AChRδ in Torpedo species through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRδ, also known as CMS2A, FCCMS, SCCMS, or CHRND, is a 517 amino acid multi-pass membrane protein that plays a crucial role in neuromuscular transmission by forming part of the nicotinic acetylcholine receptor complex. This receptor is essential for muscle contraction, as AChRδ mediates fast synaptic transmission at the neuromuscular junction by allowing cation influx when activated by acetylcholine. Mutations or dysfunctions in AChRδ are associated with severe neuromuscular disorders, including lethal type multiple pterygium syndrome and congenital myasthenic syndromes, which can lead to significant muscle weakness and respiratory failure. AChRδ interaction with other subunits of the nicotinic receptor complex is critical for structural integrity and functional efficacy, highlighting AChRδ importance in maintaining synaptic health and muscle function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor delta/CHRND Antibody (138) | sc-65806 | 200 µg/ml | $316.00 |