Nicotinic Acetylcholine Receptor delta/CHRND Antibody (137): sc-65760

AChRδ Antibody (137) is a rat monoclonal IgM antibody that detects AChRδ in mouse, rat, and Torpedo by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRδ, also known as CMS2A, FCCMS, SCCMS, or CHRND, is a 517 amino acid multi-pass membrane protein that plays a crucial role in neuromuscular transmission and is associated with several congenital myasthenic syndromes, including lethal type multiple pterygium syndrome. AChRδ is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRδ forms part of the nicotinic acetylcholine receptor complex. Proper functioning of AChRδ is vital for muscle contraction and overall neuromuscular health, as AChRδ facilitates the flow of ions in response to acetylcholine binding, thereby initiating muscle action. Disruptions in AChRδ function can lead to severe neuromuscular disorders, highlighting AChRδ′s importance in maintaining synaptic integrity and communication. Anti-AChRδ antibody (137) is an essential tool for researchers studying these critical pathways and the underlying mechanisms of related diseases.

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Nicotinic Acetylcholine Receptor delta/CHRND Antibody (137) References:

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The preferred Nicotinic Acetylcholine Receptor delta/CHRND antibody is Nicotinic Acetylcholine Receptor delta/CHRND Antibody (C-4): sc-390896.