Nicotinic Acetylcholine Receptor delta/CHRND Antibody (127): sc-65799
- Nicotinic Acetylcholine Receptor delta/CHRND Antibody (127) is a rat monoclonal IgG2b provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRδ of Torpedo origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor delta/CHRND Antibody (127). This work is in progress.
AChRδ Antibody (127) is a rat monoclonal IgG2b antibody that detects AChRδ in Torpedo species through applications such as western blotting (WB) and immunofluorescence (IF). AChRδ, also known as CMS2A, FCCMS, SCCMS, or CHRND, is a 517 amino acid multi-pass membrane protein that plays a crucial role in neuromuscular transmission by forming part of the nicotinic acetylcholine receptor complex. This receptor is essential for muscle contraction, as AChRδ mediates fast synaptic transmission at the neuromuscular junction by allowing cation influx when activated by acetylcholine. Proper functioning of AChRδ is vital, as mutations or dysfunctions in this protein are associated with severe neuromuscular disorders, including lethal type multiple pterygium syndrome and congenital myasthenic syndromes, both slow-channel and fast-channel types. Localization of AChRδ at the postsynaptic membrane is particularly important, as this positioning ensures effective response to neurotransmitter release, facilitating rapid communication between nerve and muscle cells. Anti-AChRδ antibody (127) is an invaluable tool for researchers studying these critical pathways and the underlying mechanisms of neuromuscular diseases.
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Nicotinic Acetylcholine Receptor delta/CHRND Antibody (127) References:
- Alteration of N6-methyladenosine modification profiles in the neutrophilic RNAs following ischemic stroke. | Fan, J., et al. 2024. Neuroscience. 553: 56-73. PMID: 38945353
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor delta/CHRND Antibody (127) | sc-65799 | 200 µg/ml | $316.00 |