Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody (267): sc-65821
- Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody (267) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against purified AChR from brain tissue homogenate of chicken origin
- recommended for detection of nicotinic AChRα5/α2 of avian origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody (267). This work is in progress.
AChRα5/α2 Antibody (267) is a rat monoclonal IgG2a antibody that detects AChRα5/α2 in avian species through applications such as western blotting (WB) and immunofluorescence (IF). AChRα5 and AChRα2 are integral components of the nicotinic acetylcholine receptor family, which plays a crucial role in fast synaptic transmission by mediating the flow of ions across the cell membrane in response to acetylcholine binding. These receptors are primarily located at the postsynaptic membrane of the neuromuscular junction and in the central nervous system, where they facilitate rapid communication between neurons and muscle cells. The structural composition of these receptors, consisting of five homologous subunits that form a transmembrane aqueous pore, is essential for their function, as the conformational changes induced by neurotransmitter binding allow for the selective passage of ions, thereby influencing neuronal excitability and muscle contraction. Understanding the dynamics of AChRα5 and AChRα2 is vital for elucidating the mechanisms underlying synaptic transmission and the potential implications in neuromuscular disorders. Anti-AChRα5/α2 antibody (267) is an invaluable tool for researchers investigating these critical processes in avian models.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody (267) | sc-65821 | 200 µg/ml | $322.00 |