Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (313): sc-58605

AChRα3 Antibody (313) is a rat monoclonal IgG2a antibody that detects AChRα3 protein of mouse, rat, and avian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-AChRα3 antibody (313) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AChRα3, also known as CHRNA3, is a critical component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission by mediating fast synaptic transmission in the nervous system. AChRα3 is primarily located at the postsynaptic membrane of the neuromuscular junction, where binding acetylcholine leads to the opening of an ion channel that allows the influx of cations, such as sodium and calcium, which is essential for muscle contraction and signal propagation. Proper functioning of AChRα3 is crucial for neuromuscular communication, and any dysfunction can lead to various neuromuscular disorders. AChRα3, also referred to as LNCR2, PAOD2, NACHRA3, or CHRNA3, consists of 505 amino acids and is characterized as a multi-pass membrane protein, highlighting its complex structure and functional significance in the ligand-gated ion channel receptor family.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (313) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (313) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (313) Specifications

Alternate Product Name: CHRNA3

Product Clone Name: 313

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: AChRα3

Epitope Species: chicken

Product Reactivity/Detection: both native and denatured detergent solubilized nicotinic AChRα3

Species Reactivity/Detection: mouse, rat, avian

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (313): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 antibody is Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 Antibody (C-6): sc-365479.