Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (71): sc-65826

AChRα1 Antibody (71) is a rat monoclonal IgG1 antibody that detects AChRα1 in mouse, rat, and bovine samples through applications such as western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This multi-pass membrane protein, consisting of 482 amino acids, is essential for the proper functioning of the neuromuscular junction, where AChRα1 facilitates the binding of acetylcholine and the subsequent influx of ions that trigger muscle contraction. AChRα1 exists in two alternatively spliced isoforms, with isoform 1 being exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms is significant as this pattern suggests distinct functional roles in different tissues, contributing to the complexity of synaptic transmission and muscle activation. Anti-AChRα1 antibody (71) is an invaluable tool for researchers studying the dynamics of neurotransmitter signaling and the physiological implications of AChRα1 in both health and disease.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (71) References:

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2. Homology modelling of the Apis mellifera nicotinic acetylcholine receptor (nAChR) and docking of imidacloprid and fipronil insecticides and their metabolites.  |  Rocher, A. and Marchand-Geneste, N. 2008. SAR QSAR Environ Res. 19: 245-61. PMID: 18484497
3. Gene expression profiling of rat fetuses exposed to 2-dimensional ultrasound.  |  Hocevar, Z., et al. 2012. J Ultrasound Med. 31: 923-32. PMID: 22644689
4. Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.  |  Alberola-Die, A., et al. 2016. Front Mol Neurosci. 9: 12. PMID: 26912995
5. Gene Polymorphisms for Both Auto-antigen and Immune-Modulating Proteins Are Associated with the Susceptibility of Autoimmune Myasthenia Gravis.  |  Li, HF., et al. 2017. Mol Neurobiol. 54: 4771-4780. PMID: 27501803
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7. AChRs Degeneration at NMJ in Aging-Associated Sarcopenia-A Systematic Review.  |  Bao, Z., et al. 2020. Front Aging Neurosci. 12: 597811. PMID: 33362532
8. CHRNA1 induces sarcopenia through neuromuscular synaptic elimination.  |  Liao, Z., et al. 2022. Exp Gerontol. 166: 111891. PMID: 35809807
9. A novel phenotype of AChR-deficiency syndrome with predominant facial and distal weakness resulting from the inclusion of an evolutionary alternatively-spliced exon in CHRNA1.  |  Rodríguez Cruz, PM., et al. 2023. Neuromuscul Disord. 33: 161-168. PMID: 36634413
10. An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.  |  Patel, RN., et al. 2023. Biochem Pharmacol. 216: 115758. PMID: 37604290

The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.