Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (157): sc-65831

AChRα1 Antibody (157) is a rat monoclonal IgG2a antibody that detects AChRα1 in mouse, rat, and Torpedo by western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This multi-pass membrane protein consists of 482 amino acids and exists in two alternatively spliced isoforms, with isoform 1 being specifically expressed in skeletal muscle and isoform 2 found in a variety of tissues, including skeletal muscle, brain, heart, kidney, liver, lung, and thymus. The presence of AChRα1 at the postsynaptic membrane of the neuromuscular junction is essential for muscle contraction, as AChRα1 binds acetylcholine and facilitates the flow of ions through its transmembrane pore, thereby initiating muscle action. The importance of AChRα1 extends beyond muscle function; AChRα1 is also involved in synaptic plasticity and cognitive processes in the central nervous system, highlighting its significance in both peripheral and central nervous system signaling. The activity of AChRα1 is tightly regulated, with the termination of acetylcholine signaling mediated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine, ensuring precise control over synaptic transmission. Anti-AChRα1 antibody (157) is an invaluable tool for researchers studying the dynamics of neurotransmission and the role of nicotinic receptors in various physiological and pathological contexts.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (157) References:

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2. Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.  |  Unwin, N., et al. 2002. J Mol Biol. 319: 1165-76. PMID: 12079355
3. Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients.  |  Vogt, J., et al. 2008. Am J Hum Genet. 82: 222-7. PMID: 18179903
4. The molecular anatomy of human Hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis.  |  Gammazza, AM., et al. 2012. Cell Mol Neurobiol. 32: 943-7. PMID: 22258649
5. High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection.  |  Chang, PM., et al. 2013. Ann Surg Oncol. 20: 3648-54. PMID: 23775407
6. Ancestral Reconstruction Approach to Acetylcholine Receptor Structure and Function.  |  Prinston, JE., et al. 2017. Structure. 25: 1295-1302.e3. PMID: 28689969
7. Treatment of slow-channel congenital myasthenic syndrome in a Thai family with fluoxetine.  |  Dejthevaporn, C., et al. 2022. J Clin Neurosci. 96: 85-89. PMID: 34999496
8. Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization.  |  Iacomino, N., et al. 2023. Biomedicines. 11: PMID: 36979710
9. Chromosomal localization of the mouse titin gene and its relation to 'muscular dystrophy with myositis' and nebulin genes on chromosome 2.  |  Müller-Seitz, M., et al. 1993. Genomics. 18: 559-61. PMID: 8307566
10. Muscle-type nicotinic acetylcholine receptor delta subunit determines sensitivity to noncompetitive inhibitors, while gamma subunit regulates divalent permeability.  |  Francis, MM. and Papke, RL. 1996. Neuropharmacology. 35: 1547-56. PMID: 9025102

The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.