ACE2 Antibody (E-11): sc-390851

ACE2 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACE2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ACE2 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACE2 plays a crucial role in the renin-angiotensin system, primarily functioning as a negative regulator of angiotensin II, a potent vasopressor that contributes to hypertension and cardiovascular diseases. By converting angiotensin II into angiotensin-(1-7), ACE2 helps to counteract the effects of angiotensin II, promoting vasodilation and reducing blood pressure. This balance is vital for maintaining cardiovascular health and preventing conditions such as heart failure and stroke. ACE2 is predominantly expressed in cardiac, renal, and testicular tissues, distinguishing ACE2 from ACE homolog, which is found throughout the vasculature. Such specific localization in these tissues underscores ACE2′s importance in regulating blood pressure and fluid balance, as well as ACE2′s potential role in various pathophysiological conditions, including viral infections where ACE2 serves as a receptor for the SARS-CoV-2 virus.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ACE2 Antibody (E-11) References:

1. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.  |  Donoghue, M., et al. 2000. Circ Res. 87: E1-9. PMID: 10969042
2. Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs.  |  Thekkumkara, TJ., et al. 1992. Nucleic Acids Res. 20: 683-7. PMID: 1311831
3. Angiotensin-converting enzyme: vascular endothelial localization.  |  Caldwell, PR., et al. 1976. Science. 191: 1050-1. PMID: 175444
4. Angiotensin-converting enzyme and the regulation of vasoactive peptides.  |  Soffer, RL. 1976. Annu Rev Biochem. 45: 73-94. PMID: 183603
5. The mRNAs encoding the two angiotensin-converting isozymes are transcribed from the same gene by a tissue-specific choice of alternative transcription initiation sites.  |  Kumar, RS., et al. 1991. J Biol Chem. 266: 3854-62. PMID: 1847388
6. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.  |  Ni, W., et al. 2020. Crit Care. 24: 422. PMID: 32660650
7. ACE2-based decoy receptors for SARS coronavirus 2.  |  Jing, W. and Procko, E. 2021. Proteins. 89: 1065-1078. PMID: 33973262
8. Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury.  |  Bengs, S., et al. 2021. Sci Rep. 11: 23993. PMID: 34907257
9. Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome.  |  Varillas-Delgado, D., et al. 2023. Int J Mol Sci. 24: PMID: 38069039
10. An enzyme in microsomal fraction of kidney that inactivates bradykinin.  |  Erdos, EG. and Yang, HY. 1967. Life Sci. 6: 569-74. PMID: 4962200
11. Molecular and catalytic properties of rabbit testicular dipeptidyl carboxypeptidase.  |  El-Dorry, HA., et al. 1982. J Biol Chem. 257: 14128-33. PMID: 6754723
12. Regulated expression of testis angiotensin-converting enzyme during spermatogenesis in mice.  |  Langford, KG., et al. 1993. Biol Reprod. 48: 1210-8. PMID: 8391328

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACE2 Antibody (E-11) has 99 citations in a variety of scientific publications.

Primary antibodies like Anti-ACE2 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACE2 Antibody (E-11) Specifications

Alternate Product Name: ACE2

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 631-805

Epitope Target: ACE2

Epitope Species: human

Product Reactivity/Detection: ACE2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 99 citations in various scientific publications

Available Conjugates/Forms for ACE2 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin