ACCβ Antibody (A-10): sc-390522
- ACCβ Antibody (A-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 84-109 of ACCβ of rat origin
- recommended for detection of ACCβ of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ACCβ Antibody (A-10) for WB applications. This reagent is now offered in a bundle with ACCβ Antibody (A-10) (see ordering information below).
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ACCβ Antibody (A-10) is a mouse monoclonal IgG2a antibody that detects acetyl-CoA carboxylase beta (ACCβ) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACCβ plays a crucial role in regulating fatty acid metabolism, particularly in controlling mitochondrial fatty acid oxidation, which is vital for energy production in cells. This regulation is achieved through the inhibition of carnitine-palmitoyl-CoA transferase I by malonyl-CoA, a product of ACCβ′s enzymatic activity, thereby influencing the uptake and oxidation of fatty acids in mitochondria. The gene encoding ACCβ is located on human chromosome 12 and is predominantly expressed in heart and skeletal muscle, highlighting ACCβ′s importance in tissues with high energy demands. The unique structure of ACCβ, which includes a catalytic core homologous to ACCα but with an additional 150 amino acids at the N terminus, suggests specialized regulatory mechanisms that may be critical for function in different cellular contexts. Anti-ACCβ antibody (A-10) is an essential tool for researchers studying lipid metabolism and its implications in metabolic disorders.
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ACCβ Antibody (A-10) References:
- Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver. | Oh, SY., et al. 2003. J Biol Chem. 278: 28410-7. PMID: 12764144
- Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2. | Cho, YS., et al. 2008. Proteins. 70: 268-72. PMID: 17876819
- Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. | Kaushik, VK., et al. 2009. Biochim Biophys Acta. 1794: 961-7. PMID: 19236960
- Association of ACACB polymorphisms with obesity and diabetes. | Riancho, JA., et al. 2011. Mol Genet Metab. 104: 670-6. PMID: 21908218
- Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. | Abu-Elheiga, L., et al. 2012. J Biol Chem. 287: 12578-88. PMID: 22362781
- Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy. | Xu, Y., et al. 2014. Metabolism. 63: 716-26. PMID: 24650564
- Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy. | Xin, W., et al. 2015. Biochem Biophys Res Commun. 463: 364-9. PMID: 26022126
- miR-205-5p negatively regulates hepatic acetyl-CoA carboxylase β mRNA in lipid metabolism of Oreochromis niloticus. | Tao, YF., et al. 2018. Gene. 660: 1-7. PMID: 29574186
- Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor. | Correia, C., et al. 2024. Cells. 13: PMID: 39195229
- Cloning of human acetyl-CoA carboxylase-beta and its unique features. | Ha, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 11466-70. PMID: 8876158
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACCβ Antibody (A-10) | sc-390522 | 200 µg/ml | $316.00 | |||
ACCβ Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-540808 | 200 µg Ab; 10 µg BP | $354.00 | |||
ACCβ (A-10) Neutralizing Peptide | sc-390522 P | 100 µg/0.5 ml | $68.00 |