ACCβ Activators
ACCβ activators encompass a group of chemicals that can activate the activity of ACCβ, a key enzyme involved in fatty acid synthesis, through various mechanisms. These activators, such as Insulin, Leptin, and Glucose, can directly or indirectly enhance ACCβ activity by modulating its phosphorylation state, sensitivity to substrates, or substrate availability. For example, Insulin directly activates ACCβ by promoting its dephosphorylation and activation through the PI3K/Akt pathway. Leptin indirectly activates ACCβ by stimulating AMPK through the JAK2/STAT3 pathway, which reduces malonyl-CoA levels. Glucose indirectly activates ACCβ by increasing citrate levels, enhancing its sensitivity to substrate binding.
Other chemicals like Metformin, AICAR, and 8-Br-cAMP exert their activatory effects on ACCβ by stimulating AMPK, which in turn phosphorylates and inhibits ACC, leading to reduced malonyl-CoA levels and enhanced ACCβ activity. Rosiglitazone and Berberine activate ACCβ indirectly by promoting fatty acid storage and stimulating AMPK through calcium signaling, respectively. Adiponectin, Epinephrine, and Glucagon activate ACCβ indirectly by stimulating AMPK or PKA through specific receptors, resulting in phosphorylation and inhibition of ACCβ. These ACCβ activators play crucial roles in regulating fatty acid synthesis and related metabolic processes, providing insights into strategies for metabolic modulation and research applications.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates ACCβ directly by promoting its dephosphorylation and activation. This hormone triggers the PI3K/Akt pathway, leading to ACCβ activation through dephosphorylation. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Ob (hBA-147) can activate ACCβ indirectly by stimulating AMPK through the JAK/STAT pathway. AMPK activation can enhance ACCβ activity by reducing malonyl-CoA levels. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose indirectly activates ACCβ by increasing citrate levels in the cytoplasm, which allosterically activates ACCβ by enhancing its sensitivity to substrate binding. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates ACCβ indirectly by stimulating AMPK through the LKB pathway. AMPK phosphorylates and inhibits ACC, leading to reduced malonyl-CoA levels. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR can activate ACCβ indirectly by activating AMPK through an AMP-mimicking mechanism, which phosphorylates and inhibits ACC, reducing malonyl-CoA levels. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
Br-cAMP can activate ACCβ indirectly by elevating intracellular cAMP levels, leading to PKA activation. PKA can phosphorylate and activate ACCβ, enhancing its carboxylase activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone activates ACCβ indirectly by promoting fatty acid uptake and storage, which reduces the demand for malonyl-CoA, thereby enhancing ACCβ activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates ACCβ indirectly by stimulating AMPK through a mechanism involving calcium signaling. AMPK activation leads to reduced ACCβ activity due to decreased malonyl-CoA levels. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine indirectly activates ACCβ by activating AMPK through β-adrenergic receptors. AMPK activation leads to ACCβ phosphorylation and inhibition, reducing malonyl-CoA levels. | ||||||