ACADVL Antibody (D-11): sc-271225

ACADVL Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects ACADVL in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ACADVL, also known as very long chain acyl-Coenzyme A dehydrogenase, plays a crucial role in lipid metabolism by catalyzing the first step of the fatty acid beta-oxidation pathway, specifically targeting long-chain and very long chain fatty acid esters. This enzymatic function is vital for the proper breakdown of fatty acids, which are essential for energy production and cellular function. Deficiencies in ACADVL can lead to very long chain acyl-CoA dehydrogenase deficiency, a serious autosomal recessive disorder that manifests in various phenotypes, including severe childhood forms that can result in high mortality rates and cardiomyopathy, as well as milder forms with lower mortality and adult presentations characterized by myoglobinuria and rhabdomyolysis. The existence of two isoforms of ACADVL, resulting from alternative splicing, further highlights the complexity of regulation and function within the cell. Anti-ACADVL antibody (D-11) serves as an invaluable tool for researchers studying lipid metabolism and related disorders.

The preferred ACADVL antibody is ACADVL Antibody (H-7): sc-376239.