Ac-MMP9 Antibody (4A3): sc-21736

Ac-MMP-9 Antibody (4A3) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect acetylated matrix metalloproteinase-9 (Ac-MMP-9), a key enzyme involved in the degradation of extracellular matrix components. Anti-Ac-MMP-9 antibody (4A3) is raised against a specific acetylated epitope encompassing amino acids 107-115 of human Ac-MMP-9, allowing for the selective recognition of the acetylated form of MMP-9. Matrix metalloproteinase-9 plays a significant role in various physiological and pathological processes, including tissue remodeling, angiogenesis, and inflammation, by breaking down proteins such as collagen, gelatin, fibronectin, and laminin. The acetylation of MMP-9 is a crucial post-translational modification that regulates enzymatic activity, stability, and interaction with other cellular proteins, thereby influencing function in cellular processes and disease progression. Anti-Ac-MMP-9 antibody (4A3) specifically recognizes the acetylated form of MMP-9 in human samples and does not cross-react with non-acetylated MMP-9 or other lysine acetylation sites, ensuring precise detection in various experimental settings. Ac-MMP-9 monoclonal antibody (4A3) is recommended for applications including western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), making this tool valuable for researchers investigating the regulation and role of Ac-MMP-9 in conditions such as cancer metastasis, arthritis, and cardiovascular diseases. By enabling the targeted detection of acetylated MMP-9, anti-Ac-MMP-9 antibody (4A3) facilitates a deeper understanding of the molecular mechanisms governing extracellular matrix remodeling and its impact on disease mechanisms.

The preferred MMP9 antibody is MMP9 Antibody (2C3): sc-21733.