ABHD5 Antibody (36A): sc-100468
- ABHD5 Antibody (36A) is a mouse monoclonal IgG1 κ, cited in 13 publications, provided at 100 µg/ml
- raised against recombinant ABHD5 of human origin
- recommended for detection of ABHD5 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ABHD5 Antibody (36A). This work is in progress.
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ABHD5 Antibody (36A) is a mouse monoclonal IgG1 antibody that detects ABHD5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ABHD5, also known as abhydrolase domain containing 5, CGI-58, or NCIE2, is a 349 amino acid protein characterized by an alpha/beta-hydrolase domain, which is essential for catalytic activity. ABHD5 is primarily localized to the surface of lipid droplets, where ABHD5 plays a crucial role in lipolysis, the process of breaking down fats for energy. By interacting with Perilipin, ABHD5 facilitates the mobilization of stored lipids, making ABHD5 vital for maintaining lipid homeostasis in the body. Deficiencies in ABHD5 can lead to Chanarin-Dorfman syndrome, a serious autosomal recessive disorder that disrupts lipid metabolism and results in a range of symptoms, including congenital generalized ichthyosis, hepatomegaly, and neurosensory hearing loss. Anti-ABHD5 antibody (36A) effectively detects ABHD5 in various applications, making anti-ABHD5 antibody (36A) an invaluable tool for researchers studying lipid metabolism and related disorders.
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ABHD5 Antibody (36A) References:
- Molecular Basis of ABHD5 Lipolysis Activation. | Sanders, MA., et al. 2017. Sci Rep. 7: 42589. PMID: 28211464
- Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis. | Shang, S., et al. 2019. Cancer Res. 79: 5513-5526. PMID: 31439546
- The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. | Jebessa, ZH., et al. 2019. Nat Metab. 1: 1157-1167. PMID: 31742248
- Downregulated ABHD5 Aggravates Insulin Resistance of Trophoblast Cells During Gestational Diabetes Mellitus. | Peng, HY., et al. 2020. Reprod Sci. 27: 233-245. PMID: 32046372
- ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway. | Chen, G., et al. 2021. J Biol Chem. 296: 100104. PMID: 33219129
- ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation. | Gu, Y., et al. 2021. Nat Commun. 12: 6711. PMID: 34795238
- Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator. | Tseng, YY., et al. 2022. Sci Rep. 12: 2565. PMID: 35173175
- Molecular Modeling of ABHD5 Structure and Ligand Recognition. | Shahoei, R., et al. 2022. Front Mol Biosci. 9: 935375. PMID: 35836935
- ABHD5-A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions. | Schratter, M., et al. 2022. Metabolites. 12: PMID: 36355098
- FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway. | Li, J., et al. 2024. Cell Biol Toxicol. 40: 62. PMID: 39093497
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABHD5 Antibody (36A) | sc-100468 | 100 µg/ml | $339.00 |