ABCG2 Antibody (6D171): sc-69988
- ABCG2 Antibody (6D171) is a mouse monoclonal IgG2a, cited in 7 publications, provided at 50 µg/0.5 ml
- raised against amino acids 271-396 of ABCG2 of human origin
- recommended for detection of ABCG2 of mouse, rat and human origin by WB, IP, IF and IHC(P); non cross-reactive with the human MDR1, MRP1 and MRP2 gene products
- See ABCG2 (B-1): sc-377176 for ABCG2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ABCG2 Antibody (6D171). This work is in progress.
ABCG2 Antibody (6D171) is a mouse monoclonal IgG2a antibody that detects ABCG2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-ABCG2 antibody (6D171) is available in a non-conjugated form and targets the ATP-binding cassette (ABC) transporter known as ABCG2, which plays a crucial role in cellular transport mechanisms. This half-transporter, also referred to as the placenta-specific ABC transporter and breast cancer resistance protein (BCRP1), is vital for conferring resistance to various chemotherapeutic agents, including anthracyclines and topotecan, thereby influencing treatment outcomes in cancer therapy. ABCG2 is predominantly located in the plasma membrane of cells, particularly in the placenta, liver, intestine, and various stem cells, where ABCG2 functions to protect against toxic substances by facilitating their efflux from the cell. ABCG2 expression in stem cells is particularly significant, as ABCG2 contributes to the side population phenotype, which is a hallmark of stem cell characteristics and differentiation. Additionally, ABCG2 may undergo post-translational modifications such as N-linked glycosylation, which can affect stability and function, and ABCG2 has been shown to dimerize in vivo, further influencing transport capabilities. The comprehensive understanding of ABCG2′s role in drug resistance and stem cell biology underscores the importance of ABCG2 (6D171) monoclonal antibody in research and therapeutic applications.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABCG2 Antibody (6D171) References:
- Role of ABCG2/BCRP in biology and medicine. | Krishnamurthy, P. and Schuetz, JD. 2006. Annu Rev Pharmacol Toxicol. 46: 381-410. PMID: 16402910
- ABCG2: structure, function and role in drug response. | Polgar, O., et al. 2008. Expert Opin Drug Metab Toxicol. 4: 1-15. PMID: 18370855
- ABCG2 transporter: therapeutic and physiologic implications in veterinary species. | Mealey, KL. 2012. J Vet Pharmacol Ther. 35: 105-12. PMID: 21645015
- Molecular pharmacology of ABCG2 and its role in chemoresistance. | Stacy, AE., et al. 2013. Mol Pharmacol. 84: 655-69. PMID: 24021215
- BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications. | Hira, D. and Terada, T. 2018. Biochem Pharmacol. 147: 201-210. PMID: 29031817
- Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism. | Mózner, O., et al. 2019. Cells. 8: PMID: 31597297
- The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy. | Khot, MI., et al. 2020. Photodiagnosis Photodyn Ther. 29: 101579. PMID: 31639455
- Medically Important Alterations in Transport Function and Trafficking of ABCG2. | Homolya, L. 2021. Int J Mol Sci. 22: PMID: 33801813
- ABCG2 Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids. | Gochenauer, AE., et al. 2022. Genes (Basel). 13: PMID: 36553444
- Roles of the ABCG2 Transporter in Protoporphyrin IX Distribution and Toxicity. | Qi, Q., et al. 2024. Drug Metab Dispos. 52: 1201-1207. PMID: 38351044
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABCG2 Antibody (6D171) | sc-69988 | 50 µg/0.5 ml | $316.00 |