ABCD3 Antibody (F-1): sc-514728
- ABCD3 Antibody (F-1) is a mouse monoclonal IgG1 κ ABCD3 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 280-475 of ABCD3 of human origin
- ABCD3 Antibody (F-1) is recommended for detection of ABCD3 of human origin by WB, IP, IF and ELISA
- Anti-ABCD3 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ABCD3 Antibody (F-1) for WB applications. These reagents are now offered in bundles with ABCD3 Antibody (F-1) (see ordering information below).
ABCD3 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ABCD3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ABCD3 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ABCD3 plays a crucial role in the transport of very long-chain fatty acids into peroxisomes, where they undergo β-oxidation, a vital metabolic process for lipid metabolism and cellular energy production. Disruptions in this transport mechanism can lead to the accumulation of toxic fatty acids, contributing to various peroxisomal disorders, including X-linked adrenoleukodystrophy (X-ALD). ABCD3 is predominantly located in the peroxisomal membrane, where ABCD3 functions alongside other ATP-binding cassette transporters, such as ABCD1 and ABCD2, to maintain cellular lipid homeostasis. The presence of ABCD3 in irregularly shaped vesicles suggests ABCD3′s involvement in the formation and maintenance of functional peroxisomes, which are essential for cellular health. Understanding ABCD3 function and localization is critical for elucidating the pathophysiology of peroxisomal disorders and developing targeted therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABCD3 Antibody (F-1) References:
- Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. | Gärtner, J., et al. 1993. Genomics. 15: 412-4. PMID: 8449508
- A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. | Lombard-Platet, G., et al. 1996. Proc Natl Acad Sci U S A. 93: 1265-9. PMID: 8577752
- Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice. | Savary, S., et al. 1997. Eur J Hum Genet. 5: 99-101. PMID: 9195160
- Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. | Moser, HW. 1997. Brain. 120 (Pt 8): 1485-508. PMID: 9278636
- Identification of a fourth half ABC transporter in the human peroxisomal membrane. | Shani, N., et al. 1997. Hum Mol Genet. 6: 1925-31. PMID: 9302272
- Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. | Holzinger, A., et al. 1998. FEBS Lett. 426: 238-42. PMID: 9599016
- Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia. | Shimada, Y., et al. 1998. J Hum Genet. 43: 115-22. PMID: 9621516
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABCD3 Antibody (F-1) | sc-514728 | 200 µg/ml | $316.00 | |||
ABCD3 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-531210 | 200 µg Ab; 10 µg BP | $354.00 | |||
ABCD3 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-524832 | 200 µg Ab, 40 µg BP | $354.00 | |||
ABCD3 Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-544436 | 200 µg Ab; 20 µg BP | $354.00 | |||
ABCD3 Antibody (F-1) AC | sc-514728 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ABCD3 Antibody (F-1) HRP | sc-514728 HRP | 200 µg/ml | $316.00 | |||
ABCD3 Antibody (F-1) FITC | sc-514728 FITC | 200 µg/ml | $330.00 | |||
ABCD3 Antibody (F-1) PE | sc-514728 PE | 200 µg/ml | $343.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 488 | sc-514728 AF488 | 200 µg/ml | $357.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 546 | sc-514728 AF546 | 200 µg/ml | $357.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 594 | sc-514728 AF594 | 200 µg/ml | $357.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 647 | sc-514728 AF647 | 200 µg/ml | $357.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 680 | sc-514728 AF680 | 200 µg/ml | $357.00 | |||
ABCD3 Antibody (F-1) Alexa Fluor® 790 | sc-514728 AF790 | 200 µg/ml | $357.00 |