A-FABP Antibody (B-4): sc-271529

A-FABP Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects A-FABP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A-FABP (B-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. A-FABP protein, also known as adipocyte fatty acid-binding protein, plays a crucial role in lipid metabolism by facilitating the uptake, transport, and targeting of fatty acids within adipose tissue. A-FABP is predominantly located in adipocytes, where A-FABP accounts for approximately 1% of the total cytosolic protein, highlighting A-FABP′s significance in energy homeostasis and metabolic regulation. The human A-FABP gene, organized into four exons, is mapped to chromosome 8q21 and encodes a 132-amino acid protein that is essential for maintaining the balance between lipid and carbohydrate metabolism. By mediating both passive and protein-mediated transport of fatty acids, A-FABP influences various physiological processes, including insulin sensitivity and inflammation, making A-FABP a vital target for research in metabolic disorders and obesity.

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A-FABP Antibody (B-4) References:

1. The fatty acid transport function of fatty acid-binding proteins.  |  Storch, J. and Thumser, AE. 2000. Biochim Biophys Acta. 1486: 28-44. PMID: 10856711
2. Unravelling the significance of cellular fatty acid-binding proteins.  |  Glatz, JF. and Storch, J. 2001. Curr Opin Lipidol. 12: 267-74. PMID: 11353329
3. Fatty acid-binding proteins of nervous tissue.  |  Veerkamp, JH. and Zimmerman, AW. 2001. J Mol Neurosci. 16: 133-42; discussion 151-7. PMID: 11478368
4. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA.  |  Baxa, CA., et al. 1989. Biochemistry. 28: 8683-90. PMID: 2481498
5. A-FABP links obesity and breast cancer.  |  Greenhill, C. 2018. Nat Rev Endocrinol. 14: 566. PMID: 30143798
6. A-FABP in Metabolic Diseases and the Therapeutic Implications: An Update.  |  Li, HL., et al. 2021. Int J Mol Sci. 22: PMID: 34502295
7. Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening.  |  Yang, S., et al. 2022. RSC Adv. 12: 13500-13510. PMID: 35520131
8. Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes.  |  Karasek, D., et al. 2022. J Clin Med. 11: PMID: 35566542
9. Circulating AFABP, FGF21, and PEDF Levels as Prognostic Biomarkers of Sight-threatening Diabetic Retinopathy.  |  Lee, CH., et al. 2023. J Clin Endocrinol Metab. 108: e799-e806. PMID: 36856742
10. Levofloxacin alleviates blood-brain barrier disruption following cerebral ischemia and reperfusion via directly inhibiting A-FABP.  |  Yang, S., et al. 2024. Eur J Pharmacol. 963: 176275. PMID: 38113968
11. Cytoplasmic fatty acid-binding proteins: their structure and genes.  |  Veerkamp, JH. and Maatman, RG. 1995. Prog Lipid Res. 34: 17-52. PMID: 7644552
12. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.  |  Hotamisligil, GS., et al. 1996. Science. 274: 1377-9. PMID: 8910278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-A-FABP Antibody (B-4) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-A-FABP Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

A-FABP Antibody (B-4) Specifications

Alternate Product Name: FABP4

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 106-132

Epitope Target: A-FABP

Epitope Species: human

Product Reactivity/Detection: A-FABP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for A-FABP Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred B-FABP antibody is B-FABP Antibody (F-6): sc-374588.