Adenylate cyclase 3/AC3/ADCY3 Antibody (C-5): sc-518064
- Adenylate cyclase 3/AC3/ADCY3 Antibody (C-5) is a mouse monoclonal IgM provided at 200 µg/ml
- specific for an epitope mapping between amino acids 22-46 within an N-terminal cytoplasmic domain of A cyclase III of human origin
- recommended for detection of A cyclase III of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Adenylate cyclase 3/AC3/ADCY3 Antibody (C-5). This work is in progress.
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A cyclase III Antibody (C-5) is a mouse monoclonal IgM antibody that detects A cyclase III in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A cyclase III (C-5) antibody plays a crucial role in studying cellular signaling by converting ATP to cyclic AMP in response to the activation of G protein-coupled receptors, particularly those coupled with the Golf protein. This conversion is vital as cyclic AMP serves as a second messenger that regulates various physiological processes, including neurotransmission, hormone signaling, and cardiac function. The unique structure of A cyclase III, which includes specific domains that interact with G proteins, allows selective activation, leading to precise control over cyclic AMP levels in response to different stimuli. This specificity is essential for maintaining cellular homeostasis and ensuring signaling pathways are activated only when necessary, thereby preventing dysregulation that could lead to diseases such as heart failure or neurological disorders. Anti-A cyclase III antibody (C-5) is an invaluable tool for researchers studying these critical signaling pathways and their implications in health and disease.
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Adenylate cyclase 3/AC3/ADCY3 Antibody (C-5) References:
- The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation. | Rendell, M., et al. 1975. J Biol Chem. 250: 4253-60. PMID: 1126950
- Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. | Celano, M., et al. 2003. Mol Cell Endocrinol. 203: 129-35. PMID: 12782409
- The class III adenylyl cyclases: multi-purpose signalling modules. | Linder, JU. and Schultz, JE. 2003. Cell Signal. 15: 1081-9. PMID: 14575863
- Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. | Choi, EJ., et al. 1992. Biochemistry. 31: 6492-8. PMID: 1633161
- Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. | Bishop, GA., et al. 2007. J Comp Neurol. 505: 562-71. PMID: 17924533
- Phosphorylation of adenylyl cyclase III at serine1076 does not attenuate olfactory response in mice. | Cygnar, KD., et al. 2012. J Neurosci. 32: 14557-62. PMID: 23077041
- Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes. | Chen, X., et al. 2016. Biol Psychiatry. 80: 836-848. PMID: 26868444
- Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons. | Yang, J., et al. 2020. Mol Neurobiol. 57: 3042-3056. PMID: 32458389
- Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice. | Zhang, WW., et al. 2022. JCI Insight. 7: PMID: 34914639
- Heme b inhibits class III adenylyl cyclases. | Elsabbagh, S., et al. 2023. Cell Signal. 103: 110568. PMID: 36565898
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenylate cyclase 3/AC3/ADCY3 Antibody (C-5) | sc-518064 | 200 µg/ml | $322.00 |