Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8): sc-518057

A cyclase III Antibody (E-8) is a mouse monoclonal IgG2a antibody that detects A cyclase III in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A cyclase III (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. A cyclase III, also known as adenylate cyclase 3, plays a crucial role in cellular signaling by converting ATP to cyclic AMP, a vital second messenger that mediates the effects of hormones and neurotransmitters. The elevation of cyclic AMP is essential for regulating numerous physiological processes, including metabolism, gene expression, and neuronal signaling, which are critical for memory and learning. A cyclase III is primarily located in the plasma membrane of neurons and other cell types, where A cyclase III is strategically positioned to respond to extracellular signals. This localization enables rapid signal transduction from G protein-coupled receptors, leading to swift cellular responses. A cyclase III is uniquely activated by the Golf protein, which is involved in olfactory signaling, highlighting specialized function in sensory perception. Understanding A cyclase III dynamics and interactions with other signaling molecules can provide insights into roles in health and disease, making anti-A cyclase III antibody (E-8) an invaluable tool for researchers studying these pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8) References:

1. FlCRhR/cyclic AMP signaling in myenteric ganglia and calbindin-D28 intrinsic primary afferent neurons involves adenylyl cyclases I, III and IV.  |  Liu, CY., et al. 1999. Brain Res. 826: 253-69. PMID: 10224303
2. Guanylyl cyclases as a family of putative odorant receptors.  |  Gibson, AD. and Garbers, DL. 2000. Annu Rev Neurosci. 23: 417-39. PMID: 10845070
3. Heterologous sensitization of recombinant adenylate cyclases by activation of D(2) dopamine receptors.  |  Cumbay, MG. and Watts, VJ. 2001. J Pharmacol Exp Ther. 297: 1201-9. PMID: 11356947
4. A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones.  |  Parkinson, NA. and Bolsover, SR. 2001. Brain Res Mol Brain Res. 91: 43-9. PMID: 11457491
5. Adenylyl cyclases.  |  Tang, WJ. and Gilman, AG. 1992. Cell. 70: 869-72. PMID: 1525824
6. Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin.  |  Choi, EJ., et al. 1992. Biochemistry. 31: 6492-8. PMID: 1633161
7. Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1.  |  Charania, MA., et al. 2009. J Bacteriol. 191: 4298-306. PMID: 19395492
8. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
9. Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.  |  Antal, MC., et al. 2017. PLoS One. 12: e0170756. PMID: 28122017
10. G proteins: transducers of receptor-generated signals.  |  Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
11. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.  |  Zhang, WW., et al. 2022. JCI Insight. 7: PMID: 34914639
12. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.  |  Taussig, R., et al. 1994. J Biol Chem. 269: 6093-100. PMID: 8119955

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8) Specifications

Alternate Product Name: ADCY3

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 24-44

Epitope Target: A cyclase III

Epitope Species: human

Product Reactivity/Detection: A cyclase III

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 3/AC3/ADCY3 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin