5α-Reductase 2 Antibody (1F4): sc-293232

5α-Reductase 2 Antibody (1F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects 5α-Reductase 2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-5α-Reductase 2 antibody (1F4) is available as non-conjugated format. 5α-Reductase 2 protein plays a crucial role in androgen metabolism, specifically converting testosterone to the more biologically active 5α-dihydrotestosterone (DHT), which is essential for developing and maintaining male secondary sexual characteristics. 5α-Reductase 2 is predominantly expressed in the prostate and vital for normal prostate function, as well as hair follicle development and function. Dysregulation of 5α-Reductase 2 activity has been implicated in various conditions, including androgenetic alopecia and benign prostatic hyperplasia. 5α-Reductase 2 features a unique catalytic site that allows for specific binding and conversion of steroid hormones, making 5α-Reductase 2 a target for therapeutic interventions in androgen-related disorders. Understanding 5α-Reductase 2 function and regulation is important for developing treatments for conditions linked to androgen excess or deficiency, highlighting anti-5α-Reductase 2 antibody (1F4)′s significance in research and clinical applications.

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5α-Reductase 2 Antibody (1F4) References:

1. Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain.  |  Steckelbroeck, S., et al. 2001. J Clin Endocrinol Metab. 86: 1324-31. PMID: 11238528
2. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions.  |  Suzuki, T., et al. 2001. J Clin Endocrinol Metab. 86: 2250-7. PMID: 11344235
3. 5alpha-reductase-2 deficiency and complete androgen insensitivity: lessons from nature.  |  Imperato-McGinley, J. 2002. Adv Exp Med Biol. 511: 121-31; discussion 131-4. PMID: 12575759
4. Gender change in 46,XY persons with 5alpha-reductase-2 deficiency and 17beta-hydroxysteroid dehydrogenase-3 deficiency.  |  Cohen-Kettenis, PT. 2005. Arch Sex Behav. 34: 399-410. PMID: 16010463
5. Fetal distribution of 5alpha-reductase 1 and 5alpha-reductase 2, and their input on human prostate development.  |  Lunacek, A., et al. 2007. J Urol. 178: 716-21. PMID: 17574609
6. DSD due to 5α-reductase 2 deficiency - from diagnosis to long term outcome.  |  Costa, EM., et al. 2012. Semin Reprod Med. 30: 427-31. PMID: 23044880
7. The effect of 5α-reductase-2 deficiency on human fertility.  |  Kang, HJ., et al. 2014. Fertil Steril. 101: 310-6. PMID: 24412121
8. Paternity in 5α-Reductase-2 Deficiency: Report of Two Brothers with Spontaneous or Assisted Fertility and Literature Review.  |  Bertelloni, S., et al. 2019. Sex Dev. 13: 55-59. PMID: 30889611
9. Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride.  |  Xiao, Q., et al. 2020. Nat Commun. 11: 5430. PMID: 33110062
10. Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas.  |  Bonkhoff, H., et al. 1996. Prostate. 29: 261-7. PMID: 8876709
11. Expression of rat steroid 5 alpha-reductase (isozyme-1) in Spodoptera frugiperda, SF21, insect cells: expression of rat steroid 5 alpha-reductase.  |  Taylor, MF., et al. 1997. Steroids. 62: 373-8. PMID: 9090798
12. Evidence of heterogeneity and quantitative differences of the type 1 5alpha-reductase expression in cultured human skin cells--evidence of its presence in melanocytes.  |  Chen, W., et al. 1998. J Invest Dermatol. 110: 84-9. PMID: 9424094

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-5α-Reductase 2 Antibody (1F4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-5α-Reductase 2 Antibody (1F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

5α-Reductase 2 Antibody (1F4) Specifications

Alternate Product Name: 5α-Reductase 2

Product Clone Name: 1F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 28-65

Epitope Target: 5α-Reductase 2

Epitope Species: human

Product Reactivity/Detection: 5α-Reductase 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for 5α-Reductase 2 Antibody (1F4): N/A