4E-T Antibody (E-4): sc-514810

4E-T Antibody (E-4) is a mouse monoclonal IgG1 antibody that detects eIF4E-Transporter (4E-T) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4E-T plays a crucial role in regulating eIF4E, a key component of the eukaryotic initiation complex eIF4F, which is essential for protein synthesis initiation. By facilitating eIF4E nuclear import, 4E-T ensures eIF4E availability in the nucleus to bind to the mRNA "cap," a critical step in the translation process. The interaction between 4E-T and eIF4E occurs through a conserved binding site, highlighting the specificity of this interaction. Additionally, 4E-T contains a bipartite nuclear localization signal and two leucine-rich nuclear export signals, which are vital for nucleocytoplasmic transport function. The gene encoding 4E-T is located on human chromosome 22q11.2, making 4E-T an important target for studies related to gene expression and protein synthesis regulation. With the ability to facilitate proper localization and function of eIF4E, 4E-T remains integral to maintaining cellular homeostasis and responding to various physiological stimuli.

The preferred 4E-T antibody is 4E-T Antibody (B-3): sc-393788.