4E-T Activators
4E-T Activators pertains to a group of compounds that exert their influence on the cellular machinery through the modulation of the 4E-T protein. The 4E-T protein, or eukaryotic translation initiation factor 4E-binding protein, plays a crucial role in the regulation of mRNA translation. Specifically, it functions as a repressor by binding to the eukaryotic translation initiation factor 4E (eIF4E), a key factor involved in the initiation of cap-dependent translation. This interaction impedes the formation of the eIF4F complex, which is essential for the initiation of protein synthesis.
Members of the 4E-T Activators class demonstrate the capacity to modify the activity of 4E-T protein, thereby influencing the intricate balance of translation initiation. Through their molecular interactions, these compounds can either enhance or attenuate the binding affinity between 4E-T and eIF4E, consequently impacting the overall translational efficiency within the cell. The modulation of 4E-T activity by these compounds represents a potential avenue for fine-tuning cellular protein synthesis, a process fundamental to various cellular functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that could potentially stimulate the activity of 4E-T indirectly through the inhibition of the mTOR pathway, a controller of eIF4E-mediated translation. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
An mTOR inhibitor that might stimulate 4E-T activity indirectly by controlling the mTOR pathway, hence influencing eIF4E-mediated translation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that could potentially incite 4E-T activity by inhibiting the PI3K/Akt/mTOR pathway, an upstream activator of eIF4E. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor that could potentially incite 4E-T activity indirectly by inhibiting PI3K, a key element in the PI3K/Akt/mTOR pathway that activates eIF4E. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
An Akt inhibitor that might indirectly spur 4E-T activity by inhibiting Akt, a component of the PI3K/Akt/mTOR pathway that activates eIF4E. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
An Akt inhibitor that might indirectly stimulate 4E-T activity by inhibiting Akt, part of the PI3K/Akt/mTOR pathway that activates eIF4E. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An ERK inhibitor that might indirectly stimulate 4E-T activity by inhibiting the ERK/MAPK pathway, which can incite eIF4E activity. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
A MEK inhibitor that might indirectly spur 4E-T activity by inhibiting MEK, a component of the ERK/MAPK pathway that incites eIF4E activity. | ||||||