4E-BP1 Antibody (11G12C11): sc-81149
- 4E-BP1 Antibody (11G12C11) is a mouse monoclonal IgG1 κ, cited in 16 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to the N-terminal 118 amino acids of 4E-BP1 of human origin
- Anti-4E-BP1 Antibody (11G12C11) is recommended for detection of 4E-BP1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-4E-BP1 Antibody (11G12C11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of 4E-BP1 (11G12C11): sc-81149.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for 4E-BP1 Antibody (11G12C11) for WB and IHC(P) applications. This reagent is now offered in a bundle with 4E-BP1 Antibody (11G12C11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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4E-BP1 Antibody (11G12C11) is a mouse monoclonal IgG1 kappa light chain antibody that detects 4E-BP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-4E-BP1 antibody (11G12C11) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 4E-BP1 plays a crucial role in regulating protein synthesis by acting as a translational repressor. 4E-BP1 binds to eukaryotic translation initiation factor 4E (eIF-4E), preventing formation of the eIF-4F complex essential for translation initiation. Phosphorylation of 4E-BP1 by various kinases, such as S6 kinase p70, MAP kinases, or protein kinase C, leads to dissociation from eIF-4E, promoting translation of mRNAs critical for cell growth and proliferation. This regulatory mechanism is particularly important in cancer biology, where dysregulation of protein synthesis can contribute to tumorigenesis. 4E-BP1 also interacts with 4E-BP2, which modulates eIF-4E activity, highlighting the complexity of translational control in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4E-BP1 Antibody (11G12C11) | sc-81149 | 200 µg/ml | $316.00 | |||
4E-BP1 Antibody (11G12C11): m-IgGκ BP-HRP Bundle | sc-521165 | 200 µg Ab, 40 µg BP | $354.00 | |||
4E-BP1 Antibody (11G12C11) AC | sc-81149 AC | 500 µg/ml, 25% agarose | $416.00 | |||
4E-BP1 Antibody (11G12C11) HRP | sc-81149 HRP | 200 µg/ml | $316.00 | |||
4E-BP1 Antibody (11G12C11) FITC | sc-81149 FITC | 200 µg/ml | $330.00 | |||
4E-BP1 Antibody (11G12C11) PE | sc-81149 PE | 200 µg/ml | $343.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 488 | sc-81149 AF488 | 200 µg/ml | $357.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 546 | sc-81149 AF546 | 200 µg/ml | $357.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 594 | sc-81149 AF594 | 200 µg/ml | $357.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 647 | sc-81149 AF647 | 200 µg/ml | $357.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 680 | sc-81149 AF680 | 200 µg/ml | $357.00 | |||
4E-BP1 Antibody (11G12C11) Alexa Fluor® 790 | sc-81149 AF790 | 200 µg/ml | $357.00 |