4.1N Antibody (F-2): sc-514652

4.1N Antibody (F-2) is a mouse monoclonal IgG2b antibody that detects 4.1N protein in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1N, also known as band 4.1-like protein 1 or neuronal protein 4.1, plays a crucial role in binding and stabilizing D2 and D3 dopamine receptors at the neuronal plasma membrane, which is essential for maintaining synaptic integrity and neurotransmission. 4.1N protein is predominantly expressed in the brain, where 4.1N contributes to the stability and plasticity of neuronal membranes by mediating interactions between the cytoskeleton and the plasma membrane. Additionally, 4.1N protein is present at lower levels in other tissues such as the heart, kidney, pancreas, placenta, lung, and skeletal muscle, indicating diverse functional roles across different organ systems. The complexity of the 4.1 family is further highlighted by the presence of four homologous genes (4.1R, 4.1G, 4.1N, and 4.1B), which undergo intricate alternative splicing, suggesting that these spliced products may be involved in the targeting of specific transmembrane proteins in kidney epithelium, thereby regulating essential kidney functions. Anti-4.1N antibody (F-2) is an invaluable tool for researchers studying the dynamics of dopamine receptor interactions and the broader implications of 4.1N in neuronal health and disease.

The preferred 4.1N antibody is 4.1N Antibody (B-2): sc-374367.