4.1B Antibody (B-6): sc-398089

4.1B Antibody (B-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects 4.1B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-4.1B antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 4.1B (B-6) monoclonal antibody plays a crucial role in studying cytoskeletal architecture of cells, particularly in the nervous system, where 4.1B is involved in maintaining structural integrity and mechanical properties of the cell membrane. 4.1B belongs to the 4.1 gene family, which includes 4.1R, 4.1G, and 4.1N, and is essential for stabilizing spectrin-actin interactions, vital for shape and function of erythrocytes and neurons. Unique distribution of 4.1B in the brain suggests involvement in synaptic function and neuronal signaling, making 4.1B a significant target for studies related to neurobiology and hematological disorders. Anti-4.1B antibody (B-6) detects multiple forms of 4.1B, which may vary in their functional roles within different cellular contexts, further underscoring the importance of this research tool.

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4.1B Antibody (B-6) References:

1. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain.  |  Parra, M., et al. 2000. J Biol Chem. 275: 3247-55. PMID: 10652311
2. Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes.  |  Ohara, R., et al. 2000. Brain Res Mol Brain Res. 85: 41-52. PMID: 11146105
3. Protein 4.1 in forebrain postsynaptic density preparations: enrichment of 4.1 gene products and detection of 4.1R binding proteins.  |  Scott, C., et al. 2001. Eur J Biochem. 268: 1084-94. PMID: 11179975
4. Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton: structure and functions in erythrocytes and nonerythroid cells.  |  Takakuwa, Y. 2000. Int J Hematol. 72: 298-309. PMID: 11185985
5. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.  |  Kontrogianni-Konstantopoulos, A., et al. 2001. J Biol Chem. 276: 20679-87. PMID: 11274145
6. Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis.  |  Terada, N., et al. 2003. Histochem Cell Biol. 120: 277-83. PMID: 14574582
7. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells.  |  Jiang, W. and Newsham, IF. 2006. Mol Cancer. 5: 4. PMID: 16420693
8. β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.  |  Jung, Y., et al. 2011. Dev Dyn. 240: 271-7. PMID: 21181944
9. Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer.  |  Takahashi, Y., et al. 2012. Breast Cancer. 19: 242-52. PMID: 21526423
10. Band 4.1 proteins regulate integrin-dependent cell spreading.  |  Jung, Y. and McCarty, JH. 2012. Biochem Biophys Res Commun. 426: 578-84. PMID: 22982319
11. DAA Treatment Failure in a HIV/HBV/HCV Co-Infected Patient Carrying a Chimeric HCV Genotype 4/1b.  |  De Francesco, MA., et al. 2022. Int J Environ Res Public Health. 19: PMID: 36141921
12. Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.  |  Peters, LL., et al. 1998. Genomics. 54: 348-50. PMID: 9828140

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-4.1B Antibody (B-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-4.1B Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

4.1B Antibody (B-6) Specifications

Alternate Product Name: 4.1B

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 654-810

Epitope Target: 4.1B

Epitope Species: mouse

Product Reactivity/Detection: 4.1B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for 4.1B Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin