3BP1 Antibody (C-12): sc-390557
- 3BP1 Antibody (C-12) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 202-223 of 3BP1 of human origin
- recommended for detection of 3BP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 3BP1 Antibody (C-12). This work is in progress.
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3BP1 Antibody (C-12) is a mouse monoclonal IgM antibody that detects 3BP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 3BP1, or SH3 domain-binding protein 1, is a 701 amino acid protein that plays a crucial role in cellular signaling by acting as a GTPase-activating protein (GAP) for Rac-related proteins, which are essential for regulating various cellular processes, including cytoskeletal dynamics and cell migration. The ability of 3BP1 to bind to the SH3 domains of key signal transduction proteins, particularly SRC-1 and GRB2, highlights its importance in modulating signaling pathways that influence cell growth and differentiation. Additionally, 3BP1 is expressed in two isoforms due to alternative splicing, featuring one BAR domain and one Rho-GAP domain, which contribute to its functional versatility. By inhibiting platelet-derived growth factor (PDGF)-induced membrane ruffling mediated by Rac, 3BP1 serves as a critical regulator of actin cytoskeleton organization, making 3BP1 a valuable target for research in cell biology and cancer studies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3BP1 Antibody (C-12) | sc-390557 | 200 µg/ml | $322.00 | |||
3BP1 (C-12) Neutralizing Peptide | sc-390557 P | 100 µg/0.5 ml | $69.00 |